Diethyl (Boc-amino)malonate
Diethyl (Boc-amino)malonate (CAS: 102831-44-7) is a key organic building block with the molecular formula (CH3)3COCONHCH(CO2CH2CH3)2 and a molecular weight of 275.30 g/mol. This ester derivative of malonic acid, featuring a tert-butoxycarbonyl protected amine, is widely employed in chemical synthesis, particularly in peptide chemistry and the preparation of non-natural amino acids. Its structure facilitates controlled reactions in complex organic transformations.
- IUPAC
- (Boc-amino)malonic acid diethyl ester,Diethyl 2-[N-(tert-butoxycarbonyl)amino]malonate
- Synonyms
- Diethyl 2-[N-(tert-butoxycarbonyl)amino]malonate(Boc-amino)malonic acid diethyl ester
Peptide Synthesis
Utilised as a crucial intermediate in solid-phase and solution-phase peptide synthesis for incorporating protected amino acid residues. It enables the construction of complex peptides and peptidomimetics.
Amino Acid Derivatives
Serves as a precursor for the synthesis of various unnatural and modified amino acids. The Boc-protected amine and malonate ester functionalities allow for diverse synthetic modifications.
Organic Synthesis
Functions as a versatile building block in general organic synthesis, enabling the introduction of protected amino malonate moieties into target molecules. Its reactivity is valuable in constructing carbon-carbon bonds.
Chemical Biology Research
Employed in the development of chemical probes and tools for biological research, aiding in the study of protein function and biochemical pathways.
| Molecular weight | 275.30 |
|---|---|
| Linear formula | (CH3)3COCONHCH(CO2CH2CH3)2 |
| Assay | 97% |
| Boiling point | 218 °C(lit.) |
| Density | 1.079 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.438(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl (Boc-amino)malonate used for?
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Diethyl (Boc-amino)malonate is primarily used as a building block in peptide synthesis, for the preparation of amino acid derivatives, and in general organic synthesis, particularly for creating non-natural amino acids and related compounds.
What are the CAS number and molecular formula for Diethyl (Boc-amino)malonate?
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The CAS number is 102831-44-7, and its linear formula is (CH3)3COCONHCH(CO2CH2CH3)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl (Boc-amino)malonate with a minimum assay of 97%. This product is suitable for research and general chemical synthesis purposes. TSS does not represent this product as USP, BP, or EP grade.
How should Diethyl (Boc-amino)malonate be handled safely?
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Diethyl (Boc-amino)malonate is classified as a warning substance, with hazards including skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Handle with appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure adequate ventilation and avoid inhalation of vapours or dust.
Is Diethyl (Boc-amino)malonate exported by Tech Serve Solutions?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including Diethyl (Boc-amino)malonate, and can fulfil international orders.
How can I request a sample or quote for Diethyl (Boc-amino)malonate?
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To request a sample or a quote for Diethyl (Boc-amino)malonate, please contact our sales team through the website or by phone, providing your specific requirements and delivery details.
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