Diethyl (2-oxobutyl)phosphonate

CAS 1067-73-8(C2H5O)2PCH2COCH2CH3Chemical Synthesis

Diethyl (2-oxobutyl)phosphonate (CAS 1067-73-8) is an organophosphorus compound with the molecular formula C8H17O4P and a molar mass of 208.19 g/mol. This reagent is a valuable intermediate in organic synthesis, primarily utilised in C-C bond formation and olefination reactions. Its applications span the preparation of complex organic molecules, including heterocyclic compounds and biologically active substances.

IUPAC: (2-Oxobutyl)phosphonic acid diethyl ester,Diethyl propanoylmethylphosphonate
Synonyms: (2-Oxobutyl)phosphonic acid diethyl esterDiethyl propanoylmethylphosphonate

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Diethyl (2-oxobutyl)phosphonate ((C2H5O)2PCH2COCH2CH3) — chemical structure, CAS 1067-73-8; Chemistry, fine chemical supplied by Tech Serve Solutions

C-C Bond FormationChemical SynthesisOlefinationSynthetic Reagents

01 /Applications

Synthesis of Heterocyclic Compounds

Serves as a key reactant in the synthesis of oxa(bicyclo)octanones, precursors to cycloheptane annulated furans, and substituted thiophenes via the Gewald reaction.

Wittig Reaction and Olefination

Employed in Wittig-type reactions for the preparation of natural products such as Anatoxin-a and its analogues, and for the synthesis of α-methylene-β-amino ketones.

Preparation of Odorants

Utilised in the synthesis of aliphatic musk odorants, contributing to the fragrance industry.

Synthesis of Oxoalkylphosphonates

Acts as a reactant in the formation of various oxoalkylphosphonates, important synthetic intermediates.

02 /Properties

Molecular weight	208.19
Linear formula	(C2H5O)2PCH2COCH2CH3
Assay	96%
Density	1.072 g/mL at 25 °C(lit.)
Refractive index	n20/D 1.4360(lit.)
Application	Reactant for synthesis of: • Oxa(bicyclo)octanone for use in preparing cycloheptane annulated furans1• Anatoxin-a and homoanatoxin via the Wittig reaction2• α-Methylene-β-amino ketones3• 2-Amino-5-phosphono- and 2-amino-4-(phosphonomethyl)thiophenes using the Gewald reaction4• Aliphatic musk odorants5• Oxoalkylphosphonates6

03 /Safety & handling

Protective equipment	Eyeshields, Gloves
Flash point	>110 °C / >230 °F
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

1067-73-8

MDL number

MFCD03427248

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Diethyl (2-oxobutyl)phosphonate used for?

Diethyl (2-oxobutyl)phosphonate is used as a reactant in organic synthesis for C-C bond formation and olefination, including the preparation of heterocyclic compounds, natural products like Anatoxin-a, α-methylene-β-amino ketones, and aliphatic musk odorants.

What is the CAS number and formula for Diethyl (2-oxobutyl)phosphonate?

The CAS number is 1067-73-8 and the linear formula is (C2H5O)2PCH2COCH2CH3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Diethyl (2-oxobutyl)phosphonate with an assay of 96%. We do not represent this product as USP, BP, or EP grade.

What are the safety and handling precautions for Diethyl (2-oxobutyl)phosphonate?

This compound has a high flash point (>110 °C / >230 °F). Recommended personal protective equipment includes eyeshields and gloves. It is classified under WGK 3 in Germany.