Diethyl (2-cyanoethyl)phosphonate
Diethyl (2-cyanoethyl)phosphonate (CAS: 10123-62-3, Formula: NC(CH2)2P(O)(OC2H5)2) is a versatile organophosphorus compound with a molecular weight of 191.16 g/mol. Utilised as a key reactant in organic synthesis, it facilitates C-C bond formation and is employed in olefination reactions. Its applications extend to the development of biologically active molecules, including intermediates for antiviral compounds and inhibitors.
- IUPAC
- (2-Cyanoethyl)-phosphonic acid diethyl ester,3-(Diethylphosphono)propionitrile,NSC 43781,NSC 74863
- Synonyms
- (2-Cyanoethyl)-phosphonic acid diethyl ester3-(Diethylphosphono)propionitrileNSC 43781NSC 74863
Heteroatom-Directed Alkynylation
Serves as a reactant for heteroatom-directed alkyl cyanation of alkynes, contributing to complex molecule synthesis.
Fluorescent Substrate for Enzyme Assays
Functions as a fluorescent substrate for carbon-phosphorous lyase, aiding in biochemical research and enzyme characterisation.
Microwave-Assisted Cleavage
Utilised in microwave-assisted cleavage reactions for phosphate, phosphonate, and phosphoramide esters, offering efficient synthetic routes.
Synthesis of Bioactive Compounds
Key reactant in the amination and stereoselective olefination for the synthesis of HIV-1 antiviral agents and other lipophilic oxoamides with phospholipase A2 inhibitory activity.
| Molecular weight | 191.16 |
|---|---|
| Linear formula | NC(CH2)2P(O)(OC2H5)2 |
| Assay | 95% |
| Boiling point | 110 °C/0.1 mmHg(lit.) |
| Density | 1.08 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4380(lit.) |
| Application | Reactant for:• Heteroatom-directed alkyl cyanation of alkynes1• Use as a fluorescent substrate for carbon-phosphorous lyase2• Microwave-assisted cleavage of phosphate, phosphonate, and phorphoramide esters3• Amination and stereoselective olefination for synthesis of HIV-1 antivirals4Reactant for synthesis of: • Base-catalyzed stereospecific anti-Markovnikov addition reactants5• Lipophilic oxoamides with activity against phospholipase A26• Triose phosphate isomerase of muscle inhibitors7 |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl (2-cyanoethyl)phosphonate used for?
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Diethyl (2-cyanoethyl)phosphonate is used as a reactant in chemical synthesis, including C-C bond formation, olefination reactions, alkyl cyanation of alkynes, and the synthesis of various biologically active compounds.
What is the CAS number and formula for Diethyl (2-cyanoethyl)phosphonate?
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The CAS number is 10123-62-3, and the linear formula is NC(CH2)2P(O)(OC2H5)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl (2-cyanoethyl)phosphonate with a purity of 95%. We do not represent this product as USP, BP, or EP grade.
How should Diethyl (2-cyanoethyl)phosphonate be handled safely?
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Diethyl (2-cyanoethyl)phosphonate is a Warning substance that causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335). Use appropriate personal protective equipment, including eyeshields, gloves, and a suitable respirator. Ensure good ventilation.
Is Diethyl (2-cyanoethyl)phosphonate available for export?
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Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including Diethyl (2-cyanoethyl)phosphonate.
How can I request a sample or quote?
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To request a sample or quote for Diethyl (2-cyanoethyl)phosphonate, please contact our sales team through the website or by phone.
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