Dacarbazine
Dacarbazine (CAS: 4342-03-4; Formula: C6H10N6O; Molar Mass: 182.18 g/mol) is a triazine antineoplastic agent. It functions by methylating DNA, thereby interfering with DNA synthesis. Dacarbazine is recognised for its use in treating metastatic malignant melanomas and Hodgkin's lymphoma, typically in combination regimens. It has also been utilised in research settings to induce hepatotoxicity in animal models.
- IUPAC
- 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide,DTIC
- Synonyms
- 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide,DTIC
Antineoplastic Agent
Dacarbazine is primarily employed as an antineoplastic agent for the treatment of specific cancers, including metastatic malignant melanomas and Hodgkin's lymphoma. Its mechanism involves DNA methylation.
Research Chemical
In laboratory settings, Dacarbazine has been used as a research tool to induce hepatotoxicity in preclinical studies, aiding in the investigation of liver damage mechanisms.
Apoptosis Induction
This compound has been shown to induce apoptosis, programmed cell death, in human cells, making it a subject of interest in cancer research.
| Molecular weight | 182.18 |
|---|---|
| Empirical formula | C6H10N6O |
| Storage temperature | 2-8°C |
| Application | Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents. It is used to induce apoptosis in human cells1. It has been used to induce hepatotoxicity in mice2. |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H340May cause genetic defects
- H350May cause cancer
Precautionary statements
- P201Obtain special instructions before use
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P308IF exposed or concerned
| Protective equipment | Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 45-46-20/21/22-36/37/38 |
| Safety statements (S) | 53-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dacarbazine used for?
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Dacarbazine is used to treat metastatic malignant melanomas and Hodgkin's lymphoma. It functions as a triazine antineoplastic agent that causes DNA methylation and interferes with DNA synthesis. It is also used in research to induce apoptosis and hepatotoxicity.
What is the CAS number and formula for Dacarbazine?
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The CAS number for Dacarbazine is 4342-03-4, and its empirical formula is C6H10N6O.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Dacarbazine with an assay of >98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade unless explicitly stated in the product specifications.
How should Dacarbazine be handled safely?
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Dacarbazine is a Danger substance, classified with H302 + H312 + H332 (Harmful if swallowed, in contact with skin or if inhaled), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), H340 (May cause genetic defects), and H350 (May cause cancer). Always wear appropriate personal protective equipment, including eyeshields, suitable gloves, and a respirator with P3 filter, and handle in a well-ventilated area or fume hood. Refer to the Safety Data Sheet (SDS) for full details.
Is Dacarbazine a controlled substance?
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The provided data does not indicate that Dacarbazine is a controlled substance.
How is Dacarbazine packed and shipped?
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Dacarbazine is typically stored at 2-8°C. As a global supplier, Tech Serve Solutions adheres to all regulations for packing and exporting chemicals.
How can I request a sample or quote for Dacarbazine?
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To request a sample or a quote for Dacarbazine, please contact our sales team through the website or by calling us directly.
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