Dansyl chloride
Dansyl chloride (CAS: 605-65-2), a key chemical with the molecular formula C12H12ClNO2S and a molecular weight of 269.75 g/mol, is a vital fluorogenic reagent. It is primarily employed for the fluorescent N-terminal derivatization of amino acids and peptides, enabling their sensitive detection via reverse-phase HPLC. Tech Serve Solutions supplies this compound for various analytical and biochemical applications.
- IUPAC
- 5-(Dimethylamino)naphthalene-1-sulfonyl chloride,DNSCl
- Synonyms
- 5-(Dimethylamino)naphthalene-1-sulfonyl chlorideDNSCl
Amino Acid Analysis
Dansyl chloride is widely used for the fluorescent labelling of amino acids, facilitating their sensitive detection and quantification in complex biological samples using HPLC.
Peptide Sequencing
This reagent enables the fluorescent derivatization of the N-terminus of peptides, aiding in their identification and analysis in biochemical research and diagnostics.
Fluorescence Detection
Its ability to form fluorescent adducts with primary and secondary amines makes it an invaluable tool for enhanced detection limits in various chromatographic techniques.
Biochemical Research
Dansyl chloride serves as a critical reagent in studies involving biogenic amines and other amine-containing compounds where fluorescence detection is advantageous.
| Molecular weight | 269.75 |
|---|---|
| Empirical formula | C12H12ClNO2S |
| Assay | ≥99.0% (HPLC) |
| Storage temperature | 2-8°C |
| Application | A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC. |
| Suitability | suitable for fluorescence |
| Melting point | 72-74 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Product Line | BioReagent |
|---|---|
| Fluorescence | λex 337 nm; λem 492 nm in chloroform (after derivatization with hexylamine) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Dansyl chloride used for?
+
Dansyl chloride (CAS: 605-65-2) is a fluorogenic reagent used for the fluorescent N-terminal derivatization of amino acids and peptides, enabling their detection by reverse-phase HPLC.
What is the CAS number and molecular formula for Dansyl chloride?
+
The CAS number for Dansyl chloride is 605-65-2, and its molecular formula is C12H12ClNO2S.
What grade and purity does Tech Serve Solutions supply for Dansyl chloride?
+
Tech Serve Solutions supplies Dansyl chloride with an assay of ≥99.0% (HPLC), suitable for fluorescence. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling Dansyl chloride?
+
Dansyl chloride is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including eyeshields, face shields, and chemical-resistant gloves, must be worn. Ensure adequate ventilation and follow P-statements P280, P305 + P351 + P338, P310.
How is Dansyl chloride packed and shipped?
+
Dansyl chloride is typically shipped as UN 3261, Class 8, Packing Group II, under refrigerated conditions (2-8°C).
How can I request a sample or quote for Dansyl chloride?
+
To request a sample or a quotation for Dansyl chloride, please contact our sales department via the website or by telephone.
▶ Related products
![(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide (C8H13N3O4) — chemical structure, CAS 138472-01-2; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F138472-01-2.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(E)-hydroxyimino]-5-nitro-3-hexenamide
C8H13N3O4
Biochemicals & Reagents![(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide (C14H18N4O4) — chemical structure, CAS 162626-99-5; Biochemicals & Reagents, fine chemical supplied by Tech Serve Solutions](/_next/image?url=https%3A%2F%2Fpub-f4d920c906024441a773a96f7098e551.r2.dev%2Fimages%2Fproducts%2F162626-99-5.png&w=3840&q=75)
(±)-(E)-4-Ethyl-2-[(Z)-hydroxyimino]-5-nitro-3-hexen-1-yl-nicotinamide
C14H18N4O4
Biochemicals & Reagents
(±)-2,5-Dimethoxy-4-bromoamphetamine hydrobromide
Biochemicals & Reagents
(±)-2-(p-Methoxyphenoxy)propionic acid
C10H12O4
Biochemicals & Reagents
(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide
C10H13NO2·HBr
Biochemicals & Reagents
(±)-2-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxydecanoic acid
C10H20O3
Biochemicals & Reagents
(±)-3-Hydroxyoctanoic acid
C8H16O3
Biochemicals & Reagents▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis