D-Mannosamine hydrochloride

CAS 5505-63-5C6H13NO5 · HClChemical Synthesis

D-Mannosamine hydrochloride (CAS 5505-63-5, C6H13NO5 · HCl, MW: 215.63) is a valuable monosaccharide derivative crucial in biochemical research. This compound serves as a key intermediate for synthesising non-natural N-acetylmannosamine (ManNAc) analogues. These analogues are instrumental in modifying cell-surface sialic acids, enabling advanced studies in glycobiology and chemical biology. It also finds application in the development of enzyme inhibitors for conditions like osteoarthritis.

IUPAC: 2-Amino-2-deoxy-D-mannose hydrochloride
Synonyms: 2-Amino-2-deoxy-D-mannose hydrochloride

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D-Mannosamine hydrochloride (C6H13NO5 · HCl) — chemical structure, CAS 5505-63-5; Chemistry, fine chemical supplied by Tech Serve Solutions

Biochemicals and ReagentsCarbohydrate ChemistryCarbohydrate DerivativesCarbohydrate LibraryCarbohydratesCarbohydrates A to ZCarbohydrates M-OCell BiologyChemical BiologyChemical Synthesis

01 /Applications

Synthesis of Non-Natural Sialic Acid Analogues

D-Mannosamine hydrochloride is employed for synthesising modified N-acetylmannosamine (ManNAc) analogues. These analogues can be used to introduce thiols onto cell-surface sialic acids, facilitating further biochemical and cellular studies.

Enzyme Inhibitor Development

This compound has been utilised in research for creating and screening libraries of N-acetyl-β-hexosaminidase inhibitors. Such research is pertinent to developing therapeutic strategies for conditions like osteoarthritis.

Glycobiology Research

As a derivative of mannosamine, it is a useful tool in understanding carbohydrate structures and functions, particularly in cellular processes involving sialic acids and their modifications.

02 /Properties

Molecular weight	215.63
Empirical formula	C6H13NO5 · HCl
Storage temperature	2-8°C
Application	D-Mannosamine hydrochloride can be used for the synthesis of non-natural ManNAc analogs for the expression of thiols on cell-surface sialic acids. 1 It has been used in a study to investigate the synthesis and high-throughput screening of N-acetyl-β-hexosaminidase inhibitor libraries targeting osteoarthritis. 2
Melting point	168 °C (dec.)(lit.)

03 /Identifiers & registry

CAS number

5505-63-5

MDL number

MFCD00064557

PubChem substance

24896935

Beilstein registry

3914860

04 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

05 /Frequently asked questions

What is D-Mannosamine hydrochloride used for?

D-Mannosamine hydrochloride is used in synthesising non-natural ManNAc analogues for modifying cell-surface sialic acids and in developing N-acetyl-β-hexosaminidase inhibitors for research into conditions like osteoarthritis.

What are the CAS number and formula for D-Mannosamine hydrochloride?

The CAS number is 5505-63-5 and the formula is C6H13NO5 · HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies D-Mannosamine hydrochloride for research purposes. The specific assay and purity are detailed in the product specifications. TSS does not represent this product as USP, BP, or EP grade.

How should D-Mannosamine hydrochloride be handled and stored?

Refer to the Safety Data Sheet (SDS) for detailed handling instructions. Based on available data, it has a melting point of 168°C (dec.) and a WGK Germany classification of 3. It should be stored at 2-8°C.

Can D-Mannosamine hydrochloride be exported by Tech Serve Solutions?

Yes, Tech Serve Solutions is a global supplier and exporter of fine chemicals, including D-Mannosamine hydrochloride, adhering to all relevant shipping regulations.

How can I request a quote or sample for D-Mannosamine hydrochloride?

To request a quote or sample, please contact the Tech Serve Solutions sales department via our website or direct inquiry channels, providing the product name and CAS number (5505-63-5).