D-Mannitol

CAS 69-65-8C6H14O6Chemical Synthesis

D-Mannitol (CAS: 69-65-8, C6H14O6) is a naturally occurring hexahydroxy alcohol known for its sweet taste and osmotic properties. With a molecular weight of 182.17 g/mol, this crystalline solid is widely recognised for its use as a pharmaceutical excipient, particularly as a diluent in tablet formulations and as an osmotic diuretic. Its chemical structure and properties also lend themselves to applications in research and chemical synthesis.

IUPAC: Mannite,Mannitolum
Synonyms: ManniteMannitolum

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D-Mannitol (C6H14O6) — chemical structure, CAS 69-65-8; Chemistry, fine chemical supplied by Tech Serve Solutions

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01 /Applications

Pharmaceutical Excipient

D-Mannitol serves as a crucial excipient in the pharmaceutical industry. Its primary role is as a diluent in solid dosage forms such as tablets and capsules, providing bulk and improving compressibility. It is also recognised for its use as an osmotic diuretic.

Osmotic Diuretic

As an osmotic agent, D-Mannitol is administered intravenously to reduce intracranial and intraocular pressure. This therapeutic application leverages its ability to draw water from tissues into the bloodstream.

Chemical Synthesis and Research

In laboratory settings, D-Mannitol acts as a valuable starting material and reagent in various chemical synthesis pathways. Its carbohydrate structure makes it useful in biochemical and chemical biology research.

02 /Properties

Molecular weight	182.17
Empirical formula	C6H14O6
Assay	≥98% (GC)
Grade	SAJ first grade
Solubility	H2O: soluble1 M, clear, colorless
Impurities tested	≤0.0005% Phosphorus (P)≤0.01% Insoluble matter
Melting point	167-170 °C(lit.)

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	2
Cation traces	Al: ≤0.0005%Ca: ≤0.0005%Cu: ≤0.0005%Fe: ≤0.0005%K: ≤0.005%Mg: ≤0.0005%NH4+: ≤0.05%Na: ≤0.005%Pb: ≤0.001%Zn: ≤0.0005%
Anion traces	chloride (Cl-): ≤0.05%sulfate (SO42-): ≤0.05%
Ignition residue	≤0.01%

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

69-65-8

Beilstein registry

1721898

05 /Additional specifications

Availability	available only in Japan

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is D-Mannitol used for?

D-Mannitol is primarily used as a pharmaceutical excipient, particularly as a diluent in tablets, and as an osmotic diuretic in medical applications. It also finds use in chemical synthesis and research.

What is the CAS number and formula for D-Mannitol?

The CAS number for D-Mannitol is 69-65-8, and its molecular formula is C6H14O6.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies D-Mannitol in SAJ first grade with an assay of ≥98% (GC). We do not represent this product as USP, BP, or EP grade unless explicitly stated.

How should D-Mannitol be handled safely?

Safe handling of D-Mannitol requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Refer to the safety data sheet for comprehensive guidance. It has a WGK classification of 2 in Germany.