Clomipramine hydrochloride
Clomipramine hydrochloride (CAS: 17321-77-6), a tricyclic antidepressant, is chemically identified as C19H23ClN2 · HCl with a molecular weight of 351.31 g/mol. This white to off-white powder is primarily recognised for its role in inhibiting the reuptake of serotonin and noradrenaline. It is widely employed in scientific research for investigating neurotransmission pathways and related neurological functions.
- IUPAC
- 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride,Anafranil hydrochloride
- Synonyms
- 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride,Anafranil hydrochloride
Neuroscience Research
Clomipramine hydrochloride serves as a valuable tool in neuroscience for studying monoamine transporter function and its impact on neurotransmission. Its selective inhibition of serotonin and noradrenaline reuptake makes it useful for in vitro and in vivo research models.
Biochemical Assays
Utilised in biochemical assays to investigate the mechanisms of action of antidepressants and related compounds. Its well-defined inhibitory profile allows researchers to probe the intricate systems of neurotransmitter regulation.
Drug Discovery and Development
As an approved therapeutic, clomipramine hydrochloride is used as a reference compound in drug discovery programs. It aids in the development of novel therapeutic agents targeting mood disorders and other central nervous system conditions.
| Molecular weight | 351.31 |
|---|---|
| Empirical formula | C19H23ClN2 · HCl |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white to off-white |
| Solubility | H2O: soluble25 mg/mL0.1 M HCl: soluble |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22-36/37/38 |
| Safety statements (S) | 13-20/21-22-24/25-26-28-36/37/39-38-62 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Clomipramine hydrochloride used for?
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Clomipramine hydrochloride is used in research settings to study neurotransmission, particularly the reuptake mechanisms of serotonin and noradrenaline, and serves as a reference compound in drug discovery for neurological and psychiatric conditions.
What are the CAS number and formula for Clomipramine hydrochloride?
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The CAS number for Clomipramine hydrochloride is 17321-77-6, and its empirical formula is C19H23ClN2 · HCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Clomipramine hydrochloride with an assay of ≥98% (HPLC). We do not represent this product as USP, BP, or EP grade.
How should Clomipramine hydrochloride be handled?
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Handle Clomipramine hydrochloride with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves, in a well-ventilated area. Avoid dust formation and inhalation. Refer to the safety data sheet for detailed handling procedures and hazard information, as it is harmful if swallowed, in contact with skin, or if inhaled, causes skin irritation, serious eye irritation, and may cause respiratory irritation.
How is Clomipramine hydrochloride packed, shipped, and exported?
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Clomipramine hydrochloride is carefully packed to maintain its integrity during transit. Tech Serve Solutions, as a specialist global supplier and exporter, handles all necessary documentation and logistics for international shipments.
How can I request a sample or quote for Clomipramine hydrochloride?
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To request a sample or a quotation for Clomipramine hydrochloride, please contact our sales department through the website or provide your details via the product inquiry form.
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