4-Bromo-2-nitrobenzoic acid
4-Bromo-2-nitrobenzoic acid (CAS 99277-71-1) is an organic compound with the linear formula (Br)C 6 3(NO 2)CO 2H and a molecular weight of 246.01 g/mol. This white to off-white solid serves as a valuable building block in chemical synthesis. It is known to undergo Negishi-type coupling reactions, making it useful in the preparation of more complex organic molecules for research and development purposes.
Organic Synthesis Intermediate
Utilised as a key intermediate in the synthesis of diverse organic compounds. Its structure, featuring a bromine atom, a nitro group, and a carboxylic acid, allows for various chemical transformations.
Cross-Coupling Reactions
Specifically employed in Negishi-type coupling reactions with organozinc reagents, catalysed by palladium-phosphine complexes. This reaction is instrumental in forming new carbon-carbon bonds.
Building Block for Complex Molecules
Serves as a fundamental building block for constructing more elaborate molecular architectures in pharmaceutical and materials science research.
| Molecular weight | 246.01 |
|---|---|
| Linear formula | (Br)C6H3(NO2)CO2H |
| Assay | 97% |
| Application | Undergoes Negishi-type coupling with dimethylzinc in the presence of palladium-phosphine catalysis.1 |
| Melting point | 165-169 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H317May cause an allergic skin reaction
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H400Very toxic to aquatic life
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Transport (UN / ADR) | UN 3077 9 / PGIII |
| Water hazard class (WGK, DE) | 2 |
| Hazard codes (EU) | Xn,N |
| Risk statements (R) | 22-36/37/38-43-50 |
| Safety statements (S) | 26-36/37-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Bromo-2-nitrobenzoic acid used for?
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4-Bromo-2-nitrobenzoic acid is primarily used as an intermediate in organic synthesis, particularly in Negishi-type coupling reactions for the preparation of complex organic molecules.
What is the CAS number and formula for 4-Bromo-2-nitrobenzoic acid?
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The CAS number is 99277-71-1, and the linear formula is (Br)C 6 3(NO 2)CO 2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Bromo-2-nitrobenzoic acid with an assay of 97%. TSS does not represent this product as USP, BP, EP, or any pharmacopoeia grade.
How should 4-Bromo-2-nitrobenzoic acid be handled safely?
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Handle with appropriate personal protective equipment including eyeshields, gloves, and a dust mask (type N95 or equivalent). Avoid breathing dust and ensure good ventilation. It is harmful if swallowed and causes skin and eye irritation.
Is 4-Bromo-2-nitrobenzoic acid an environmentally hazardous substance?
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Yes, it is classified as very toxic to aquatic life with long-lasting effects (H400, N).
How is 4-Bromo-2-nitrobenzoic acid packed and shipped?
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The product is shipped according to UN 3077 regulations for environmentally hazardous substances. Specific packaging details can be provided upon request.
How can I request a quote or sample of 4-Bromo-2-nitrobenzoic acid?
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To request a quote or sample, please contact the TSS sales team through our website or provide your details via the contact form.
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