Chlorosulfonylacetyl chloride
Chlorosulfonylacetyl chloride (CAS 4025-77-8) is a reactive organic compound with the linear formula ClSO2CH2COCl. It is primarily used as a building block in chemical synthesis, particularly for organic chemistry research and development. This compound serves as a key intermediate in the preparation of complex molecules, including antagonists for platelet ADP receptors and for N-terminal derivatization of peptides in mass spectrometry.
Synthesis of Tricyclic Benzothiazolo Antagonists
Used in the preparation of novel tricyclic benzothiazolo [2,3-c] thiadiazine antagonists, targeting platelet ADP receptors.
Peptide N-terminal Derivatization
Employed for N-terminal derivatization of peptides, facilitating rapid sequence determination via mass spectrometry techniques.
Organic Synthesis Intermediate
Acts as a versatile building block in general organic synthesis, contributing to the construction of various complex molecular structures.
| Molecular weight | 177.01 |
|---|---|
| Linear formula | ClSO2CH2COCl |
| Assay | 95% |
| Boiling point | 71-72 °C/1 mmHg(lit.) |
| Density | 1.669 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.493(lit.) |
| Vapour pressure | 0.06 mmHg (20 °C) |
| Application | Chlorosulfonylacetyl chloride has been used in:• preparation of novel tricyclic benzothiazolo [2,3-c] thiadiazine antagonists of the platelet ADP receptor1• N-terminal derivatization of peptides in rapid determination of peptide or protein sequences by matrix-assisted laser desorption ionization mass spectrometry2 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 14-34-36/37 |
| Safety statements (S) | 26-27-28-36/37/39-45 |
| Supplemental hazards | Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chlorosulfonylacetyl chloride used for?
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Chlorosulfonylacetyl chloride is utilised as a building block in chemical synthesis. It has been specifically used for preparing novel tricyclic benzothiazolo [2,3-c] thiadiazine antagonists and for the N-terminal derivatization of peptides for mass spectrometry analysis.
What are the CAS number and formula for Chlorosulfonylacetyl chloride?
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The CAS number for Chlorosulfonylacetyl chloride is 4025-77-8 and its linear formula is ClSO2CH2COCl.
What is the purity or grade of Chlorosulfonylacetyl chloride?
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This product is supplied at an assay of 95%. It is suitable for research and chemical synthesis applications and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the main hazards associated with Chlorosulfonylacetyl chloride?
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Chlorosulfonylacetyl chloride is classified as corrosive and can cause severe skin burns and eye damage. It may also cause respiratory irritation. It reacts violently with water, posing an additional safety risk. Appropriate personal protective equipment, including gloves, eye protection, and respiratory protection, is essential when handling this chemical.
How is Chlorosulfonylacetyl chloride packed and exported?
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This chemical is packed in accordance with transport regulations, identified under UN 3265, Class 8, Packing Group II. As a global supplier, Tech Serve Solutions adheres to all relevant international shipping and export guidelines.
How can I request a quote for Chlorosulfonylacetyl chloride?
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To request a quote, please contact our sales team with your specific requirements, including the desired quantity and delivery location. You can find our contact information on the Tech Serve Solutions website.
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