Chloromethyl chlorosulfate
Chloromethyl chlorosulfate (CAS: 49715-04-0), with the linear formula ClCH₂OSO₂Cl and a molecular weight of 165.00, is a versatile chemical reagent. It serves as a valuable intermediate in organic synthesis, particularly for chloromethylation reactions. Its primary application is the efficient chloromethylation of Fmoc-protected amino acids, notably avoiding the formation of hazardous bis(chloromethyl)ether, thus enhancing laboratory safety.
Chloromethylation Reagent
Chloromethyl chlorosulfate is employed as a reagent for the selective chloromethylation of Fmoc-protected amino acids. This application is crucial in peptide synthesis and related organic chemistry research.
Synthesis of Organic Intermediates
This compound acts as a building block in the synthesis of various organic molecules. Its reactivity allows for the introduction of specific functional groups in complex synthetic pathways.
Research and Development
Utilised in research laboratories for developing new synthetic methodologies and exploring novel chemical transformations. Its specific reactivity profile makes it a subject of interest in academic and industrial R&D.
| Molecular weight | 165.00 |
|---|---|
| Linear formula | ClCH2OSO2Cl |
| Assay | 97% |
| Boiling point | 45-50 °C/10 mmHg |
| Density | 1.631 g/mL at 25 °C |
| Refractive index | n20/D 1.448 |
| Storage temperature | 2-8°C |
| Application | Reagent for chloromethylation of Fmoc-protected amino acids without the generation of carcinogenic bis(chloromethyl)ether.1 |
Hazard statements
- H272May intensify fire; oxidiser
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P220Keep away from clothing and combustible materials
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 1760 8 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chloromethyl chlorosulfate used for?
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Chloromethyl chlorosulfate (CAS: 49715-04-0) is primarily used as a reagent for the chloromethylation of Fmoc-protected amino acids, offering a safer alternative to methods that generate carcinogenic byproducts like bis(chloromethyl)ether.
What is the CAS number and formula for Chloromethyl chlorosulfate?
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The CAS number for Chloromethyl chlorosulfate is 49715-04-0 and its linear formula is ClCH₂OSO₂Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chloromethyl chlorosulfate with an assay of 97%. We do not represent this product as meeting USP, BP, EP, or any pharmacopoeia standards.
How should Chloromethyl chlorosulfate be handled safely?
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Chloromethyl chlorosulfate is a dangerous substance (Danger) that can cause severe skin burns and eye damage (H314), is harmful if swallowed (H302), and may intensify fire; oxidising (H272). Handling requires appropriate personal protective equipment, including face shields, chemical-resistant gloves, and respiratory protection suitable for corrosive vapours. Ensure adequate ventilation and avoid contact with combustible material.
How is Chloromethyl chlorosulfate packed and exported?
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This product is packed and shipped in compliance with regulations for corrosive and oxidising materials, identified under UN 1760 (Class 8, Packing Group III). Tech Serve Solutions is a specialist global supplier and exporter.
How can I request a quote or sample for Chloromethyl chlorosulfate?
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To request a quote or a sample of Chloromethyl chlorosulfate, please contact our sales team directly through our website or by phone. We will be pleased to assist with your inquiry.
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