Chloromethyl chloroformate
Chloromethyl chloroformate (CAS: 22128-62-7), with the linear formula ClCOOCH2Cl and a molecular weight of 128.94 g/mol, is a reactive acid halide. This compound serves as a crucial building block and derivatization reagent in organic synthesis. Its primary applications lie in the preparation of novel ester prodrugs and functionalised molecules for pharmaceutical research and chemical development.
Synthesis of Diclofenac and Flufenamic Acid Prodrugs
Chloromethyl chloroformate is employed as a key reactant in the synthesis of novel aminocarbonyloxymethyl esters of non-steroidal anti-inflammatory drugs like diclofenac and flufenamic acid. This facilitates the creation of modified drug forms for enhanced properties.
Development of Water-Soluble Prodrugs
This reagent is utilised in the synthesis of highly water-soluble monomethoxypoly(ethylene glycol) prodrugs of cyclosporin A. This application is vital for improving the bioavailability and administration of complex therapeutic agents.
Preparation of Triazene Derivatives
It is used in the synthesis of a series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes. These compounds can be explored for various chemical and biological applications.
| Molecular weight | 128.94 |
|---|---|
| Linear formula | ClCOOCH2Cl |
| Assay | ≥98.0% (GC) |
| Boiling point | 107-108 °C(lit.) |
| Density | 1.450 g/mL at 20 °C |
| Refractive index | n20/D 1.428 |
| Storage temperature | 2-8°C |
| Application | Chloromethyl chloroformate was used as key reactant in the synthesis of:• novel aminocarbonyloxymethyl esters of diclofenac and flufenamic acid1• highly water-soluble monomethoxypoly(ethyleneglycol) prodrugs of cyclosporin A2• series of 3-acyloxymethyloxycarbonyl-1-aryl-3-methyltriazenes3 |
Hazard statements
- H314Causes severe skin burns and eye damage
- H331Toxic if inhaled
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 95 °C / 203 °F |
| Transport (UN / ADR) | UN 2745 6.1/PG 2 |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T |
| Risk statements (R) | 23-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chloromethyl chloroformate used for?
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Chloromethyl chloroformate is primarily used as a reactant in organic synthesis for creating ester prodrugs, functionalising molecules, and preparing various organic intermediates.
What is the CAS number and formula for Chloromethyl chloroformate?
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The CAS number for Chloromethyl chloroformate is 22128-62-7, and its linear formula is ClCOOCH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chloromethyl chloroformate with an assay of ≥98.0% (GC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
How should Chloromethyl chloroformate be handled safely?
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Chloromethyl chloroformate is corrosive and toxic by inhalation (H314, H331). Handle with extreme care using appropriate personal protective equipment, including gloves, goggles, a face shield, and a suitable respirator. Ensure adequate ventilation.
How is Chloromethyl chloroformate packed, shipped, and exported?
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This chemical is carefully packed to international standards for safe transport and is available for global export by Tech Serve Solutions.
How can I request a quote or sample for Chloromethyl chloroformate?
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Please contact our sales team via the website or direct email to request a quotation or to arrange for a product sample.
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