Chloromethanesulfonyl chloride
Chloromethanesulfonyl chloride (CAS 3518-65-8) is a reactive organosulfur compound with the linear formula ClCH2SO2Cl and a molecular weight of 149.00. This chemical serves as a valuable intermediate and reagent in organic synthesis. Its primary applications lie in the introduction of the chloromethanesulfonyl group, facilitating various derivatization and protection strategies in complex molecule construction.
- IUPAC
- Chloromesyl chloride
- Synonyms
- Chloromethanesulfonyl chlorideChloromesyl chloride

Synthetic Intermediate
Chloromethanesulfonyl chloride is utilized as a building block in the synthesis of more complex organic molecules. It allows for the introduction of specific functional groups essential for further chemical transformations in multi-step syntheses.
Protecting Group Reagent
In organic chemistry, this compound can act as a reagent for the protection of functional groups. The chloromethanesulfonyl group can be selectively introduced and later removed under specific conditions, preserving sensitive moieties during reactions.
Derivatization Agent
It is employed for derivatizing molecules, which can be useful for analytical purposes or to modify the properties of a target compound. This aids in characterisation or tuning the chemical behaviour of substances.
| Molecular weight | 149.00 |
|---|---|
| Linear formula | ClCH2SO2Cl |
| Assay | ≥90% (AT) |
| Density | 1.64 g/mL at 20 °C(lit.) |


Hazard statements
- H302Harmful if swallowed
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 22-34 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chloromethanesulfonyl chloride primarily used for?
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Chloromethanesulfonyl chloride is primarily used as a synthetic intermediate and a reagent for protecting and derivatizing functional groups in organic synthesis.
What is the CAS number and chemical formula for Chloromethanesulfonyl chloride?
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The CAS number is 3518-65-8, and its linear formula is ClCH2SO2Cl.
What grade and purity does Tech Serve Solutions supply for Chloromethanesulfonyl chloride?
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Tech Serve Solutions supplies Chloromethanesulfonyl chloride with an assay of ≥90% (AT). We do not represent this product as USP, BP, EP, or other pharmacopoeial grades.
How should Chloromethanesulfonyl chloride be handled safely?
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Chloromethanesulfonyl chloride is a corrosive substance that causes severe skin burns and eye damage, and is harmful if swallowed. Handle with appropriate personal protective equipment including gloves, eye protection, and respiratory protection, in a well-ventilated area. Refer to the safety data sheet for detailed handling instructions.
How is Chloromethanesulfonyl chloride packed, shipped, and exported?
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Chloromethanesulfonyl chloride is shipped under UN 3265, Class 8, Packing Group II. As a global supplier, TSS adheres to all relevant regulations for packing, shipping, and exporting hazardous chemicals.
How can I request a sample or a quote for Chloromethanesulfonyl chloride?
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Please contact our sales team via the website or direct email to request a sample or obtain a quotation for Chloromethanesulfonyl chloride.
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