Chloro(dimethyl)phenylsilane
Chloro(dimethyl)phenylsilane (CAS: 768-33-2, Formula: C6H5Si(CH3)2Cl, MW: 170.71) is a reactive organosilicon compound. It serves as a valuable intermediate and reagent in chemical synthesis, particularly in the introduction of the dimethylphenylsilyl protecting group. Its utility extends to laboratory research and the development of novel materials and pharmaceuticals.
- IUPAC
- DMPSCl,Dimethylphenylchlorosilane,Dimethylphenylsilylchloride,Phenyldimethylchlorosilane
- Synonyms
- DMPSClDimethylphenylchlorosilaneDimethylphenylsilylchloridePhenyldimethylchlorosilane

Protecting Group Chemistry
Utilised for the temporary protection of hydroxyl and amine functionalities in organic synthesis. The dimethylphenylsilyl group offers distinct cleavage conditions compared to other silyl protecting groups.
Organosilicon Synthesis
Acts as a precursor in the synthesis of more complex organosilicon compounds and polymers. It facilitates the formation of silicon-carbon bonds.
Derivatization Reagent
Employed in analytical chemistry for derivatizing compounds to improve their chromatographic properties or detectability.
| Molecular weight | 170.71 |
|---|---|
| Linear formula | C6H5Si(CH3)2Cl |
| Assay | 98% |
| Density | 1.017 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.509(lit.) |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 62 °C / 143.6 °F |
| Transport (UN / ADR) | UN 2987 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Chloro(dimethyl)phenylsilane used for?
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Chloro(dimethyl)phenylsilane is primarily used as a reagent in chemical synthesis for introducing the dimethylphenylsilyl protecting group onto hydroxyl and amine functionalities, and as a building block for organosilicon compounds.
What are the CAS number and formula for Chloro(dimethyl)phenylsilane?
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The CAS number is 768-33-2 and the molecular formula is C6H5Si(CH3)2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Chloro(dimethyl)phenylsilane with a minimum assay of 98%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Chloro(dimethyl)phenylsilane be handled safely?
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Chloro(dimethyl)phenylsilane is classified as Danger, causing severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment including full-face shields, chemical-resistant gloves, and goggles. Ensure adequate ventilation. Refer to the Safety Data Sheet for comprehensive handling instructions.
How is Chloro(dimethyl)phenylsilane packaged and shipped?
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Chloro(dimethyl)phenylsilane is shipped as a hazardous material (UN 2987, Class 8, Packing Group II). Packaging complies with international transport regulations for corrosive substances.
How can I request a sample or quote for Chloro(dimethyl)phenylsilane?
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To request a sample or a quotation, please contact the Tech Serve Solutions sales team through our website or by email, providing your specific requirements.
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