Caffeic acid phenethyl ester

CAS 104594-70-9C17H16O4Biochemicals & Reagents

Caffeic acid phenethyl ester (CAPE), CAS 104594-70-9, with the molecular formula C17H16O4 and a molecular weight of 284.31 g/mol, is a naturally occurring compound found in propolis. It functions as a potent antioxidant and free radical scavenger. Research indicates CAPE is a specific inhibitor of the nuclear transcription factor NF-κB and shows significant effects on cellular processes, including inflammation and cell proliferation.

IUPAC: CAPE

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Caffeic acid phenethyl ester (C17H16O4) — chemical structure, CAS 104594-70-9; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsC-CHCancer ResearchCell BiologyChemopreventive AgentsD to KEnzyme InhibitorsEnzyme Inhibitors by EnzymeEnzymes

01 /Applications

NF-κB Inhibition

Caffeic acid phenethyl ester is recognised as a specific inhibitor of the nuclear transcription factor NF-κB, a key regulator in inflammatory and immune responses.

Antioxidant and Anti-inflammatory Activity

CAPE exhibits significant antioxidant properties and has been shown to suppress the lipoxygenase pathway of arachidonic acid metabolism, contributing to its anti-inflammatory effects.

Cellular Proliferation and Apoptosis Studies

This compound is investigated for its role in inhibiting the proliferation of transformed cells and for its ability to induce apoptosis in transformed fibroblasts.

HIV-1 Integrase Inhibition

Studies have demonstrated that Caffeic acid phenethyl ester acts as an inhibitor of HIV-1 integrase, an enzyme crucial for viral replication.

02 /Properties

Molecular weight	284.31
Empirical formula	C17H16O4
Assay	≥97% (HPLC)
Form	powder
Colour	off-white
Solubility	ethyl acetate: soluble50 mg/mLDMSO: solubleethanol: soluble
Storage temperature	−20°C
Application	Caffeic acid phenethyl ester (CAPE) is the active component of propolis, a honeybee hive product.1 Caffeic acid phenethyl ester is a specific inhibitor of the nuclear transcription factor, NF-κB.2 CAPE has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.3,4 Caffeic acid phenethyl ester inhibits HIV-1 integrase,5,6 and also inhibits proliferation of transformed cells.7,8 It induces apoptosis in transformed fibroblasts,9 and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.7

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P305IF IN EYES

Protective equipment	dust mask type N95 (US), Eyeshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xi
Risk statements (R)	36/37/38
Safety statements (S)	26-36

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

104594-70-9

MDL number

MFCD00866470

05 /Additional specifications

Gene Information	human ... NFKB2(4791)
Storage Condition	protect from light

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is Caffeic acid phenethyl ester used for?

Caffeic acid phenethyl ester is primarily used in research as an inhibitor of NF-κB, an antioxidant, a free radical scavenger, and for studies on cell proliferation, apoptosis, and HIV-1 integrase inhibition.

What are the CAS number and formula for Caffeic acid phenethyl ester?

The CAS number for Caffeic acid phenethyl ester is 104594-70-9, and its empirical formula is C17H16O4.

What grade and purity does Tech Serve Solutions supply for Caffeic acid phenethyl ester?

Tech Serve Solutions supplies Caffeic acid phenethyl ester with an assay of ≥97% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or pharmaceutical grade.

How should Caffeic acid phenethyl ester be handled and stored?

Caffeic acid phenethyl ester (CAS 104594-70-9) is a Warning substance (GHS07) with hazards H315, H319, and H335, indicating skin, eye, and respiratory irritation. Use appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves. Store in a cool, dry place, protected from light, ideally at -20°C.