Boc-(S)-2-thienylglycine
Boc-(S)-2-thienylglycine (CAS: 40512-56-9, C11H15NO4S) is a protected unnatural amino acid derivative featuring a thiophene ring. With a molecular weight of 257.31 g/mol, it serves as a valuable chiral building block in organic synthesis. Its primary applications lie in asymmetric synthesis and peptide chemistry, where the Boc protecting group facilitates controlled reactions and the thienyl moiety introduces unique structural elements.
- IUPAC
- (S)-2-[(tert-Butoxycarbonyl)amino]-2-(2-thienyl)acetic acid

Chiral Building Block in Synthesis
This compound is extensively used as a chiral building block for the stereoselective synthesis of complex organic molecules. The (S)-configuration and the protected amine group allow for precise incorporation into target structures.
Peptide Chemistry
In peptide synthesis, Boc-(S)-2-thienylglycine acts as an unnatural amino acid. It can be incorporated into peptide chains to modify their structure, stability, or biological activity, offering an alternative to standard amino acids.
Chemical Biology Research
Its unique structure makes it useful in chemical biology for probing biological systems or developing novel peptidomimetics. The thienyl group can influence molecular interactions and pharmacokinetic properties.
Heterocyclic Chemistry
As a derivative of thiophene, it provides a functionalised heterocyclic scaffold for further chemical modification and the synthesis of more complex heterocyclic compounds.
| Molecular weight | 257.31 |
|---|---|
| Empirical formula | C11H15NO4S |
| Assay | ≥96.5% (HPLC)97% |
| Optical activity | [α]/D -90±5°, c = 1 in ethanol |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-(S)-2-thienylglycine used for?
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Boc-(S)-2-thienylglycine is primarily used as a chiral building block in asymmetric synthesis, peptide chemistry, and chemical biology research, contributing to the creation of complex organic molecules and modified peptides.
What are the CAS number and formula for Boc-(S)-2-thienylglycine?
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The CAS number for Boc-(S)-2-thienylglycine is 40512-56-9, and its molecular formula is C11H15NO4S.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Boc-(S)-2-thienylglycine with an assay of ≥96.5% (HPLC) or 97%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling recommendations for Boc-(S)-2-thienylglycine?
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According to GHS classifications, this compound has a WGK Germany rating of 3. Recommended personal protective equipment includes eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Handle with appropriate caution in a well-ventilated area.
How is Boc-(S)-2-thienylglycine shipped and exported?
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Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. We adhere to all necessary regulations for the safe and compliant packing, shipping, and export of chemicals like Boc-(S)-2-thienylglycine.
How can I request a sample or quote for Boc-(S)-2-thienylglycine?
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To request a sample or a quote for Boc-(S)-2-thienylglycine, please contact our sales team through the appropriate channels on the Tech Serve Solutions website.
What is the storage temperature for Boc-(S)-2-thienylglycine?
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Boc-(S)-2-thienylglycine should be stored at a temperature between 2-8°C to maintain its stability and quality.
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