Boc-Phe(2-F)-OH

CAS 114873-00-6C14H18FNO4Chemical Synthesis

Boc-Phe(2-F)-OH (CAS: 114873-00-6), chemically known as N-(tert-Butoxycarbonyl)-2-fluoro-L-phenylalanine, is a valuable unnatural amino acid derivative. With a molecular weight of 283.30 g/mol and empirical formula C14H18FNO4, it plays a significant role in peptide synthesis and chemical biology. This compound serves as a crucial building block for creating modified peptides and peptidomimetics with unique structural and functional properties, often employed in drug discovery and biochemical research.

IUPAC: Boc-2-fluoro-L-phenylalanine
Synonyms: N-(tert-Butoxycarbonyl)-2-fluoro-L-phenylalanine, Boc-2-fluoro-L-phenylalanine

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Boc-Phe(2-F)-OH (C14H18FNO4) — chemical structure, CAS 114873-00-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Chemical BiologyChemical SynthesisPeptide ChemistryPhenylalanine Derivatives

01 /Applications

Peptide Synthesis

Utilised as a protected unnatural amino acid for incorporating 2-fluorophenylalanine into peptide chains. This modification can influence peptide conformation, stability, and receptor binding affinity.

Drug Discovery

Serves as a key intermediate in the synthesis of novel pharmaceutical candidates. The fluorine atom can modulate metabolic stability, lipophilicity, and binding interactions of potential drug molecules.

Chemical Biology Research

Employed in the design and synthesis of peptides for probing biological systems. Its unique properties aid in studying protein-protein interactions and developing biochemical tools.

Organic Synthesis

Acts as a chiral building block for constructing complex organic molecules that require a fluorinated phenylalanine moiety.

02 /Properties

Molecular weight	283.30
Empirical formula	C14H18FNO4
Assay	≥98.0% (TLC)
Optical activity	[α]20/D +9±1°, c = 1% in ethyl acetate
Melting point	92-98 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

114873-00-6

MDL number

MFCD00672520

Beilstein registry

5347990

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Phe(2-F)-OH used for?

Boc-Phe(2-F)-OH is primarily used in peptide synthesis, drug discovery, and chemical biology research as a protected unnatural amino acid building block.

What is the CAS number and formula for Boc-Phe(2-F)-OH?

The CAS number is 114873-00-6, and the empirical formula is C14H18FNO4.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-Phe(2-F)-OH with an assay of ≥98.0% (TLC). TSS does not represent this product as USP, BP, or EP grade.

How should Boc-Phe(2-F)-OH be handled?

Handling requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. Ensure adequate ventilation and avoid dust formation.