Boc-Phe(2-CF3)-OH
Boc-Phe(2-CF3)-OH (CAS: 167993-21-7) is a protected unnatural amino acid derivative with the molecular formula C15H18F3NO4. This compound serves as a valuable building block in chemical synthesis and peptide chemistry. Its trifluoromethyl group offers unique properties for incorporation into peptides, influencing their structure and biological activity. It is primarily used in research and development settings for creating novel molecules and peptidomimetics.
- IUPAC
- Boc-2-(trifluoromethyl)-L-phenylalanine
- Synonyms
- Boc-2-(trifluoromethyl)-L-phenylalanine

Peptide Synthesis
Used as a non-proteinogenic amino acid in solid-phase or solution-phase peptide synthesis to introduce structural modifications and altered pharmacological properties into peptide sequences.
Medicinal Chemistry
Incorporated into potential drug candidates to modulate pharmacokinetic and pharmacodynamic profiles, leveraging the electron-withdrawing and lipophilic nature of the trifluoromethyl group.
Chemical Biology Research
Employed in the design and synthesis of probes or modified biomolecules for studying biological pathways and protein interactions.
Materials Science
Investigated for its potential role in developing novel polymers or functional materials due to the unique properties conferred by the trifluoromethylphenylalanine moiety.
| Molecular weight | 333.30 |
|---|---|
| Empirical formula | C15H18F3NO4 |
| Assay | ≥98.0% (TLC) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-Phe(2-CF3)-OH used for?
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Boc-Phe(2-CF3)-OH is used as a protected unnatural amino acid building block in chemical synthesis, particularly for peptide chemistry and medicinal chemistry research.
What is the CAS number and formula for Boc-Phe(2-CF3)-OH?
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The CAS number is 167993-21-7 and the empirical formula is C15H18F3NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Boc-Phe(2-CF3)-OH with a purity of ≥98.0% (TLC). This product is supplied for research and development purposes and TSS does not represent it as USP, BP, EP, or pharmaceutical grade.
What are the safety and handling recommendations for Boc-Phe(2-CF3)-OH?
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Appropriate personal protective equipment, including eyeshields and gloves, should be worn. A type N95 (US) or type P1 (EN143) respirator filter may be necessary. The compound is classified with WGK 3 in Germany, indicating a high hazard to water.
How is Boc-Phe(2-CF3)-OH packed, shipped, and exported?
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Tech Serve Solutions ensures products are securely packed for safe transit and handles global export logistics for research chemicals.
How can I request a quote or sample for Boc-Phe(2-CF3)-OH?
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Please contact our sales team or use the online inquiry form on the Tech Serve Solutions website to request a quote or sample.
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