Boc-pentafluoro-D-phenylalanine
Boc-pentafluoro-D-phenylalanine (CAS: 136207-26-6, C14H14F5NO4) is a valuable unnatural amino acid derivative with a molecular weight of 355.26 g/mol. This compound is characterised by its protected amino group and a pentafluorinated phenyl ring, offering unique chemical properties. It is primarily utilised in chemical synthesis and peptide chemistry, particularly for introducing fluorinated residues into biomolecules or peptidomimetics to study their properties or enhance stability.
- IUPAC
- (R)-2-(Boc-amino)-3-(pentafluorophenyl)propionic acid

Peptide Synthesis
Incorporated into peptide chains to create fluorinated analogues. These modified peptides can exhibit altered conformational preferences, metabolic stability, or binding affinities, useful in drug discovery and biochemical research.
Chemical Synthesis Reagent
Serves as a building block in the synthesis of complex organic molecules. The pentafluorophenyl group can influence reactivity and physicochemical properties of the target compounds.
Chemical Biology Research
Used in studies investigating the role of fluorination in biological systems. It enables researchers to probe protein-ligand interactions or modify enzyme substrates.
Unnatural Amino Acid Derivatives
A key component in the development of novel peptides and peptidomimetics with enhanced or unique biological activities and properties.
| Molecular weight | 355.26 |
|---|---|
| Empirical formula | C14H14F5NO4 |
| Assay | ≥98.0% (HPLC) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Boc-pentafluoro-D-phenylalanine used for?
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Boc-pentafluoro-D-phenylalanine is primarily used as a building block in chemical synthesis, particularly for peptide chemistry and chemical biology research, to introduce fluorinated residues into molecules.
What is the CAS number and formula for Boc-pentafluoro-D-phenylalanine?
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The CAS number is 136207-26-6, and the empirical formula is C14H14F5NO4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Boc-pentafluoro-D-phenylalanine with a purity of ≥98.0% (HPLC). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.
What are the safety and handling precautions for this chemical?
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This compound requires appropriate personal protective equipment, including eyeshields and gloves. A type N95 (US) or type P1 (EN143) respirator filter is recommended. It has a WGK Germany rating of 3, indicating a high degree of hazard.
How is Boc-pentafluoro-D-phenylalanine packed and shipped?
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Products are carefully packed and exported according to international shipping regulations for fine chemicals.
How can I request a quote or sample?
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To request a quote or sample, please contact our sales team via the website or by phone. Please specify the product name and CAS number.
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