Boc-Lys(2-Cl-Z)-OH

CAS 54613-99-9C19H27ClN2O6Chemical Synthesis

Nα-Boc-Nε-(2-chloro-Z)-L-lysine (CAS 54613-99-9) is a protected amino acid derivative with the molecular formula C19H27ClN2O6 and a molecular weight of 414.88 g/mol. This compound is particularly valuable in peptide synthesis due to the increased stability of its 2-chloro-Z protecting group compared to the standard Z group, making it suitable for solid-phase applications requiring robust protection.

IUPAC: Nα-Boc-Nε-(2-chloro-Z)-L-lysine
Synonyms: Nα-Boc-Nε-(2-chloro-Z)-L-lysine

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Boc-Lys(2-Cl-Z)-OH (C19H27ClN2O6) — chemical structure, CAS 54613-99-9; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisLysinePeptide Chemistry

01 /Applications

Solid-Phase Peptide Synthesis

Utilized as a protected lysine building block in solid-phase peptide synthesis (SPPS). The Nε-(2-chloro-Z) protection offers enhanced stability over traditional Z-group protection, allowing for more demanding synthetic conditions.

Chemical Synthesis

Serves as an intermediate in complex organic synthesis, particularly for peptides or peptidomimetics. Its protected functional groups allow for selective manipulation and coupling reactions.

Chemical Biology Research

Employed in research focused on the synthesis of peptides with modified lysine residues for studying protein structure, function, or developing novel biological probes.

02 /Properties

Molecular weight	414.88
Empirical formula	C19H27ClN2O6
Assay	≥98.0% (T)
Optical activity	[α]20/D −11±1°, c = 2% in DMF
Storage temperature	2-8°C
Application	Protected lysine especially suited for solid phase peptide synthesis; the 2-CI-Z protection is about 50 times more stable than the Z-group.1
Melting point	70-73 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

54613-99-9

MDL number

MFCD00038386

Beilstein registry

3598068

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Lys(2-Cl-Z)-OH used for?

Boc-Lys(2-Cl-Z)-OH is primarily used as a protected lysine derivative in solid-phase peptide synthesis, offering enhanced stability due to its 2-chloro-Z protecting group.

What is the CAS number and formula for Boc-Lys(2-Cl-Z)-OH?

The CAS number is 54613-99-9 and the empirical formula (Hill notation) is C19H27ClN2O6.

What grade and purity does Tech Serve Solutions supply for Boc-Lys(2-Cl-Z)-OH?

Tech Serve Solutions supplies Boc-Lys(2-Cl-Z)-OH with an assay of ≥98.0% (T). We do not represent this product as USP, BP, EP, or pharmacopoeia grade.

How should Boc-Lys(2-Cl-Z)-OH be handled and stored?

Handling requires appropriate personal protective equipment, including eyeshields, gloves, and a P1 (EN143) or N95 respirator filter. Store at 2-8°C.

Is Boc-Lys(2-Cl-Z)-OH a hazardous substance?

This compound has a WGK Germany rating of 3, indicating it is hazardous and requires careful handling. Consult the safety data sheet for full details.