Boc-Arg(NO2)-OH

CAS 2188-18-3HN=C(NHNO2)NH(CH2)3CH(COOH)NHCOOC(CH3)3Chemical Synthesis

Nα-Boc-Nω-nitro-L-arginine (CAS: 2188-18-3) is a protected amino acid derivative. Its linear formula is HN=C(NHNO2)NH(CH2)3CH(COOH)NHCOOC(CH3)3, with a molecular weight of 319.31 g/mol. This compound is primarily utilised in peptide synthesis and chemical biology research, serving as a crucial building block for creating complex peptides and probing biological systems. Its protected nature allows for controlled incorporation into peptide chains.

IUPAC: Nα-Boc-Nω-nitro-L-arginine
Synonyms: N-alpha-Boc-N-omega-nitro-L-arginineN-tert-Butoxycarbonyl-N-nitro-L-arginineBoc-L-Arg(NO2)-OH

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Boc-Arg(NO2)-OH (HN=C(NHNO2)NH(CH2)3CH(COOH)NHCOOC(CH3)3) — chemical structure, CAS 2188-18-3; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesArginineChemical BiologyChemical SynthesisPeptide Chemistry

01 /Applications

Peptide Synthesis

Nα-Boc-Nω-nitro-L-arginine serves as a key protected amino acid in solid-phase and solution-phase peptide synthesis. The Boc protecting group on the alpha-amine and the nitro group on the side chain facilitate controlled coupling reactions.

Chemical Biology Research

This derivative is employed in chemical biology to synthesise modified peptides that can be used to study protein-protein interactions, enzyme mechanisms, or as components of peptidomimetics.

Organic Synthesis

As a specialised building block, it is valuable in complex organic synthesis requiring the incorporation of a modified arginine residue.

02 /Properties

Molecular weight	319.31
Linear formula	HN=C(NHNO2)NH(CH2)3CH(COOH)NHCOOC(CH3)3
Assay	≥98.5% (calc. based on dry substance, T)
Storage temperature	2-8°C
Impurities tested	~15% residual solvents

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours

Water hazard class (WGK, DE)	3
Risk statements (R)	19-67
Supplemental hazards	May form explosive peroxides.

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2188-18-3

MDL number

MFCD00065556

Beilstein registry

2015163

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Nα-Boc-Nω-nitro-L-arginine used for?

Nα-Boc-Nω-nitro-L-arginine is primarily used as a protected amino acid derivative in peptide synthesis and chemical biology research for the construction of modified peptides.

What are the CAS number and formula for Nα-Boc-Nω-nitro-L-arginine?

The CAS number is 2188-18-3. The linear formula is HN=C(NHNO2)NH(CH2)3CH(COOH)NHCOOC(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Nα-Boc-Nω-nitro-L-arginine with an assay of ≥98.5% (calc. based on dry substance, T), which includes approximately 15% residual solvents. This is considered a technical/research grade; TSS does not represent it as USP, BP, or EP grade.

What are the key safety and handling considerations for this compound?

This compound is classified with GHS07, a Warning signal word, and carries hazard statement H336. Precautionary statement P261 advises avoiding breathing dust. It may also form explosive peroxides. Handle with appropriate personal protective equipment in a well-ventilated area.