Apicidin
Apicidin (CAS: 183506-66-3) is a cyclic tetrapeptide antibiotic derived from microbial sources. With the empirical formula C34H49N5O6 and a molecular weight of 623.78 g/mol, it functions as a potent inhibitor of histone deacetylase (HDAC). Apicidin is recognised for its biological activity and finds utility in research settings, particularly in studies related to epigenetics and cancer biology, owing to its capacity to influence gene expression.
- IUPAC
- Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinexcarbonyl]
Histone Deacetylase (HDAC) Inhibition
Apicidin is a well-characterised inhibitor of histone deacetylases. Its ability to block HDAC activity makes it a valuable tool for researchers investigating epigenetic regulation and its role in cellular processes, including proliferation and differentiation.
Cancer Research Tool
Due to its HDAC inhibitory properties, Apicidin is employed in cancer research to explore potential therapeutic strategies. It aids in understanding how epigenetic modifications contribute to tumorigenesis and can be used to study drug resistance mechanisms.
Epigenetic Studies
As a bioactive small molecule targeting epigenetic mechanisms, Apicidin is utilised in the study of DNA-RNA transcription regulation and other chromatin-related processes. It helps elucidate the complex interplay between gene expression and cellular function.
| Molecular weight | 623.78 |
|---|---|
| Empirical formula | C34H49N5O6 |
| Assay | ≥98% (HPLC) |
| Form | solid |
| Solubility | DMSO: ~1 mg/mLacetonitrile: ~1 mg/mL |
| Storage temperature | −20°C |
| Biological source | from microbial |
Hazard statements
- H300Fatal if swallowed
- H310Fatal in contact with skin
- H330Fatal if inhaled
Precautionary statements
- P260Do not breathe dust, fume, gas, mist, vapours or spray
- P264Wash thoroughly after handling
- P280Wear protective gloves, clothing and eye/face protection
- P284Wear respiratory protection
- P302IF ON SKIN
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 2811 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T+ |
| Risk statements (R) | 26/27/28 |
| Safety statements (S) | 22-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Shipped In | wet ice |
|---|
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Apicidin used for?
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Apicidin is primarily used as a research tool for its potent inhibition of histone deacetylase (HDAC) enzymes. It is valuable in studies related to epigenetics, cancer research, and understanding cellular processes influenced by chromatin modification.
What is the CAS number and formula for Apicidin?
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The CAS number for Apicidin is 183506-66-3, and its empirical formula is C34H49N5O6.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Apicidin with an assay of ≥98% (HPLC). This product is intended for research and laboratory use and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
How should Apicidin be handled and stored?
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Apicidin is classified as toxic if swallowed, in contact with skin, or if inhaled (H300-H310-H330), requiring extreme caution. It should be stored at -20°C. Handling requires appropriate personal protective equipment, including eyeshields, face shields, gloves, and suitable respiratory protection (e.g., full-face particle respirator type N100 or P3 filter).
How is Apicidin shipped?
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Apicidin is shipped in wet ice to maintain its stability during transit.
How can I request a quote or sample for Apicidin?
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To request a quote or sample for Apicidin, please contact our sales team through the website or by phone, providing the product name and CAS number (183506-66-3).
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