Aphidicolin from Nigrospora sphaerica
Aphidicolin from Nigrospora sphaerica (CAS 38966-21-1, C20H34O4) is a bioactive diterpenoid with a molecular weight of 338.48 g/mol. Supplied by Tech Serve Solutions as a white powder, this premium-grade chemical is primarily recognised for its role in biological research, particularly concerning cell cycle regulation and apoptosis. Its ability to inhibit DNA polymerase makes it a valuable tool in molecular biology and biochemical studies.
- IUPAC
- APC
Cell Cycle Research
Aphidicolin is a potent inhibitor of eukaryotic DNA polymerase α and β. It is widely used in cell biology to arrest cells in the S phase of the cell cycle, facilitating the study of DNA replication and cell cycle progression.
Apoptosis Studies
As a modulator of DNA replication, aphidicolin can be employed to investigate the intricate pathways of programmed cell death (apoptosis) and its relationship with DNA damage and repair mechanisms.
Biochemical Research
This compound serves as a vital reagent in biochemical assays to understand the function and inhibition of DNA polymerases, contributing to the development of new therapeutic strategies and research tools.
Drug Discovery Intermediate
Aphidicolin's unique chemical structure and biological activity may position it as a lead compound or intermediate in the discovery and development of novel pharmaceuticals, especially in areas related to antineoplastic agents.
| Molecular weight | 338.48 |
|---|---|
| Empirical formula | C20H34O4 |
| Assay | ≥98% (HPLC) |
| Form | powder |
| Colour | white |
| Solubility | ethanol: soluble1 mg/mL (stable at least a week at 4°C.)DMSO: soluble10 mg/mL (stable at least six weeks at −20°C.)methanol: soluble10 mg/mLH2O: insoluble |
| Optical activity | [α]27/D +12°, c = 1 in methanol(lit.) |
| Melting point | 227-233 °C(lit.) |
| Storage temperature | 2-8°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
| Quality Level | PREMIUM |
|---|---|
| Gene Information | human ... POLA1(5422), POLD1(5424), POLG(5428) |
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Aphidicolin from Nigrospora sphaerica used for?
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Aphidicolin is primarily used in biological research as an inhibitor of eukaryotic DNA polymerases, commonly employed to arrest cells in the S phase of the cell cycle and study DNA replication and apoptosis.
What is the CAS number and molecular formula for Aphidicolin from Nigrospora sphaerica?
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The CAS number is 38966-21-1 and the molecular formula is C20H34O4.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Aphidicolin from Nigrospora sphaerica at a PREMIUM quality level with an assay of ≥98% (HPLC). TSS does not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should Aphidicolin from Nigrospora sphaerica be handled and stored?
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Handle Aphidicolin with appropriate personal protective equipment, including eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. It should be stored at 2-8°C. Consult the safety data sheet for full details.
How is Aphidicolin from Nigrospora sphaerica typically packed and shipped?
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Aphidicolin is supplied as a white powder. While specific packing details are not provided, TSS ensures suitable packaging for export and shipping, adhering to relevant regulations for chemical transport.
How can I request a quote or sample for Aphidicolin from Nigrospora sphaerica?
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To request a quote or sample, please contact our sales team through the website or by phone, providing the product name and CAS number (38966-21-1).
Is Aphidicolin from Nigrospora sphaerica a controlled substance?
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The provided data does not indicate that Aphidicolin from Nigrospora sphaerica (CAS 38966-21-1) is a controlled substance.
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