Diethyl (hydroxymethyl)phosphonate
Diethyl (hydroxymethyl)phosphonate (CAS: 3084-40-0) is an organophosphorus compound with the molecular formula HOCH₂P(O)(OC₂H₅)₂ and a molecular weight of 168.13 g/mol. It serves as a valuable reactant in chemical synthesis, particularly in C-C bond formation and olefination reactions. This compound is instrumental in preparing various phosphonate derivatives with potential biological activities and in constructing complex molecular architectures.
- IUPAC
- (Hydroxymethyl)phosphonic acid diethyl ester,Diethyl phosphonomethanol
- Synonyms
- Diethyl phosphonomethanol(Hydroxymethyl)phosphonic acid diethyl ester
Synthesis of Biologically Active Compounds
Used as a reactant in the synthesis of antiproliferative agents, including α and β-dialkoxyphosphoryl isothiocyanates. It also facilitates the preparation of phosphonates investigated for anti-HIV-1 activity.
Materials Science and Polymer Chemistry
Involved in the creation of dendritic polyglycerol anions, which have applications in L-selectin inhibition. It is also a reactant for synthesizing homo and copolymers of phosphonated norbornenes.
Organic Synthesis Reagent
Acts as a reactant in Mitsunobu reactions, a key transformation for inverting the stereochemistry of alcohols. It also participates in studies involving FBPase inhibition.
Horner-Wadsworth-Emmons Reagent Precursor
This compound is a building block for reagents used in the Horner-Wadsworth-Emmons reaction, a vital method for synthesizing alkenes.
| Molecular weight | 168.13 |
|---|---|
| Linear formula | HOCH2P(O)(OC2H5)2 |
| Boiling point | 124-126 °C/3 mmHg(lit.) |
| Density | 1.14 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.444(lit.) |
| Application | Reactant for synthesis of:• α And β-dialkoxyphosphoryl isothiocyanate used in antiproliferative studies1• Dendritic polyglycerol anions for L-selectin inhibition2• Phosphonates for anti-HIV-1 activity3• Homo and copolymers of phosphonated norbornenes4Involved in studies of FBPase inhibition by phosphonic acid-containing thaizoles5Reactant for Mitsunobu reactions6 |
| Protective equipment | Eyeshields, Gloves |
|---|---|
| Flash point | >113 °C / >235.4 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Diethyl (hydroxymethyl)phosphonate used for?
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Diethyl (hydroxymethyl)phosphonate is used as a reactant in chemical synthesis, particularly for C-C bond formation, olefination, and in the preparation of biologically active compounds, polymers, and reagents for reactions like the Horner-Wadsworth-Emmons reaction.
What is the CAS number and chemical formula?
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The CAS number is 3084-40-0 and the linear formula is HOCH₂P(O)(OC₂H₅)₂.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Diethyl (hydroxymethyl)phosphonate as a research or technical grade material. We do not represent it as USP, BP, or EP grade unless explicitly stated.
How should Diethyl (hydroxymethyl)phosphonate be handled safely?
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This compound is classified under WGK Germany 3, indicating it is hazardous to water. Handle with appropriate personal protective equipment, including eyeshields and gloves, and avoid release into the environment. It has a high flash point of >113 °C.
How is this chemical packed and shipped?
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Diethyl (hydroxymethyl)phosphonate is carefully packed according to international shipping regulations. As a global supplier and exporter, TSS ensures compliant packaging and handling for worldwide distribution.
How can I request a sample or quote?
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To request a sample or a quote for Diethyl (hydroxymethyl)phosphonate, please contact our sales department through the website or by direct inquiry, providing your specific requirements.
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