6-Chloro-3-pyridinylboronic acid
6-Chloro-3-pyridinylboronic acid (CAS: 444120-91-6), with the molecular formula C5H5BClNO2 and a molecular weight of 157.36, is a valuable organoboron compound. It serves as a key intermediate in organic synthesis, particularly in cross-coupling reactions. Its applications span pharmaceutical research and development, agrochemical innovation, and the creation of advanced materials. This versatile building block enables the introduction of the 6-chloro-3-pyridinyl moiety into complex molecular structures, facilitating the synthesis of novel compounds.
- IUPAC
- 2-Chloro-5-pyridineboronic acid
- Synonyms
- 2-Chloro-5-pyridineboronic acid
Pharmaceutical Intermediate
Used in the synthesis of active pharmaceutical ingredients (APIs), particularly where a 6-chloro-3-pyridinyl structure is required for biological activity. It facilitates the development of new therapeutic agents.
Agrochemical Synthesis
A building block for novel pesticides and herbicides. The incorporation of the chloropyridinyl group can impart specific biological activity crucial for crop protection agents.
Organic Synthesis Reagent
Employed in Suzuki-Miyaura coupling and other palladium-catalysed reactions to construct carbon-carbon bonds. It enables the efficient formation of complex heterocyclic compounds.
Materials Science
Can be utilised in the development of functional materials, such as organic light-emitting diodes (OLEDs) or polymers, where its structural features contribute to desired electronic or physical properties.
| Molecular weight | 157.36 |
|---|---|
| Empirical formula | C5H5BClNO2 |
| Assay | ≥95.0% |
| Melting point | 165 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Chloro-3-pyridinylboronic acid used for?
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6-Chloro-3-pyridinylboronic acid is primarily used as an intermediate in organic synthesis, particularly for constructing complex molecules in pharmaceutical research, agrochemical development, and materials science, often via cross-coupling reactions like the Suzuki-Miyaura coupling.
What is the CAS number and formula for 6-Chloro-3-pyridinylboronic acid?
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The CAS number is 444120-91-6, and the empirical formula is C5H5BClNO2.
What grade and purity does Tech Serve Solutions supply for 6-Chloro-3-pyridinylboronic acid?
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Tech Serve Solutions supplies 6-Chloro-3-pyridinylboronic acid with an assay of ≥95.0%. This product is suitable for research and chemical synthesis purposes. TSS does not represent it as USP, BP, EP or pharmacopoeia grade.
What are the safety precautions for handling 6-Chloro-3-pyridinylboronic acid?
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Handle with appropriate personal protective equipment, including a dust mask (type N95 US recommended), eyeshields, and gloves. Avoid breathing dust and ensure adequate ventilation. This compound is classified as a Warning, with hazards including skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335).
How is 6-Chloro-3-pyridinylboronic acid packed and shipped?
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6-Chloro-3-pyridinylboronic acid is carefully packed to maintain integrity during transport and is available for global export. Please contact us for specific shipping and handling details for your region.
How can I request a sample or quote for 6-Chloro-3-pyridinylboronic acid?
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To request a sample or a quote, please visit our website or contact our sales team directly. Provide the product name and CAS number (444120-91-6) for prompt service.
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