2,2,3,3,3-Pentafluoro-1-propanol
2,2,3,3,3-Pentafluoro-1-propanol (CAS: 422-05-9, CF3CF2CH2OH) is a highly fluorinated alcohol supplied by Tech Serve Solutions. With a molecular weight of 150.05 g/mol, this compound serves as a valuable reagent in chemical synthesis and analytical chemistry. Its unique properties make it suitable for specific derivatization techniques in gas chromatography-mass spectrometry and for the preparation of novel fluorinated organic compounds.
- IUPAC
- PFPOH
- Synonyms
- 3,3-Pentafluoro-1-propanolCF3CF2CH2OH
Derivatization Reagent in GC-MS
2,2,3,3,3-Pentafluoro-1-propanol is employed as a derivatization reagent for the sensitive detection of various biomolecules, including amino acids and neurotransmitters, in biological samples by Gas Chromatography-Mass Spectrometry (GC-MS).
Synthesis of Fluorinated Compounds
This fluorinated alcohol is utilised in organic synthesis for the preparation of trifluoromethyl ynamines and fluorinated α-keto ethers, contributing to the expanding field of fluorous chemistry.
Analytical Chemistry Applications
It has been used in the simultaneous analysis of drugs and their metabolites in biological matrices, facilitating forensic and toxicological investigations via GC-MS.
| Molecular weight | 150.05 |
|---|---|
| Linear formula | CF3CF2CH2OH |
| Assay | 97% |
| Boiling point | 80 °C/748 mmHg(lit.) |
| Density | 1.505 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.288(lit.) |
| Application | 2,2,3,3,3-Pentafluoro-1-propanol has been used:• as derivatization reagent in detection of unlabeled and 15N2 -labeled L-tryptophan, L-kynurenine, serotonin and quinolinic acid in human and rat plasma by GC-MS1• as derivatization reagent in simultaneous analysis of cocaine, cocaethylene and their possible metabolic and pyrolytic products in blood, urine and muscle by GC-MS2• preparation of trifluoromethyl ynamines which, in turn, converted aldehydes to α-trifluoromethyl-α,β-unsaturated amides3• to generate fluorinated α-keto ethers with alkenes4 and has wide applications in the expanding fluorous research area4 |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 2,2,3,3,3-Pentafluoro-1-propanol used for?
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2,2,3,3,3-Pentafluoro-1-propanol is used as a derivatization reagent in GC-MS for analysing biomolecules and drugs, and in organic synthesis for preparing fluorinated compounds such as trifluoromethyl ynamines and α-keto ethers.
What are the CAS number and formula for 2,2,3,3,3-Pentafluoro-1-propanol?
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The CAS number is 422-05-9 and the linear formula is CF3CF2CH2OH.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 2,2,3,3,3-Pentafluoro-1-propanol with an assay of 97%. TSS does not represent this product as USP, BP, or EP grade.
How should 2,2,3,3,3-Pentafluoro-1-propanol be handled?
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Handle with appropriate personal protective equipment including eyeshields, faceshields, gloves, and a suitable respirator. It is harmful if swallowed, causes skin irritation, causes serious eye irritation, and may cause respiratory irritation.
How is 2,2,3,3,3-Pentafluoro-1-propanol packed, shipped, and exported?
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2,2,3,3,3-Pentafluoro-1-propanol is carefully packed for secure transit and is available for global export by Tech Serve Solutions.
How can I request a sample or quote for 2,2,3,3,3-Pentafluoro-1-propanol?
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Please contact our sales team via the website or direct enquiry to request a sample or obtain a quotation.
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