1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (CAS 69304-37-6) is a silicon-based chemical reagent with the molecular formula C12H28Cl2OSi2 and a molecular weight of 315.43 g/mol. It is primarily utilised as a protecting and derivatizing agent in organic synthesis. This compound is supplied by Tech Serve Solutions for laboratory and research applications requiring selective functional group protection.
- IUPAC
- TIPDSiCl2
- Synonyms
- [(CH3)2CH]2Si(Cl)OSi(Cl)[CH(CH3)2]2TIPDSiCl2

Protecting Group Reagent
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane serves as an effective reagent for the protection of diols. The resulting silyl ether protects the hydroxyl groups from unwanted reactions during multi-step syntheses.
Derivatizing Agent
It can be employed as a derivatizing agent to modify organic molecules, improving their analytical properties such as volatility for gas chromatography. This aids in the identification and quantification of complex organic compounds.
Intermediate in Silicon Chemistry
This dichlorosiloxane is a valuable intermediate in the synthesis of more complex organosilicon compounds. Its reactive silicon-chlorine bonds allow for further functionalisation and polymerisation.
| Molecular weight | 315.43 |
|---|---|
| Linear formula | [(CH3)2CH]2Si(Cl)OSi(Cl)[CH(CH3)2]2 |
| Assay | ≥98.5% (GC) |
| Boiling point | 70 °C/0.5 mmHg(lit.) |
| Density | 0.986 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.454(lit.)n20/D 1.455 |

Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-28-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane used for?
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1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used as a protecting and derivatizing agent, particularly for diols, in chemical synthesis. It also serves as an intermediate in the production of organosilicon compounds.
What are the CAS number and formula for 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane?
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The CAS number is 69304-37-6 and the linear formula is [(CH3)2CH]2Si(Cl)OSi(Cl)[CH(CH3)2]2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane with an assay of ≥98.5% (GC). We do not represent this product as USP, BP, or EP grade.
What are the safety and handling considerations for this product?
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This compound is classified as Danger (GHS05) and causes severe skin burns and eye damage (H314). Appropriate personal protective equipment, including face shields, chemical-resistant gloves, and respiratory protection, must be used. Handle in a well-ventilated area.
How is 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane packed and shipped?
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This product is shipped as UN 3265, Class 8, Packing Group II, adhering to strict regulations for hazardous materials transport.
How can I request a sample or quote?
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To request a sample or a quotation for 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, please contact our sales team through the website or by phone.
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