6-Chloro-3-pyridineboronic acid pinacol ester
6-Chloro-3-pyridineboronic acid pinacol ester (CAS 444120-94-9) is a heteroaryl boronate ester with the molecular formula C11H15BClNO2 and a molecular weight of 239.51 g/mol. This compound serves as a valuable building block in organic synthesis, particularly in cross-coupling reactions. It is widely employed in the development of novel pharmaceuticals and advanced materials.
- IUPAC
- 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- Synonyms
- 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Suzuki-Miyaura Cross-Coupling Reactions
This boronate ester is a key reagent for Suzuki-Miyaura cross-coupling reactions, enabling the formation of carbon-carbon bonds with aryl or vinyl halides. Its use facilitates the synthesis of complex biaryl compounds, which are common motifs in drug discovery.
Pharmaceutical Intermediate
The compound acts as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its pyridine core and boronate ester functionality make it suitable for constructing molecules with diverse biological activities.
Materials Science
6-Chloro-3-pyridineboronic acid pinacol ester can be utilised in the development of novel organic materials, such as conjugated polymers or organic light-emitting diodes (OLEDs), due to its heterocyclic structure and ability to participate in polymerisation reactions.
| Molecular weight | 239.51 |
|---|---|
| Empirical formula | C11H15BClNO2 |
| Assay | 97% |
| Melting point | 86-90 °C |
Hazard statements
- H319Causes serious eye irritation
Precautionary statements
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36 |
| Safety statements (S) | 26 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 6-Chloro-3-pyridineboronic acid pinacol ester used for?
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This compound is primarily used as a building block in organic synthesis, particularly in Suzuki-Miyaura cross-coupling reactions, and as an intermediate in the synthesis of pharmaceuticals and advanced materials.
What are the CAS number and chemical formula?
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The CAS number is 444120-94-9, and the empirical formula is C11H15BClNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 6-Chloro-3-pyridineboronic acid pinacol ester with a minimum assay of 97%. This product is supplied for research and development purposes and is not represented as USP, BP, EP, or any other pharmacopoeia grade.
What are the safety and handling precautions?
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This compound is classified as a Warning (GHS07) and causes serious eye irritation (H319). Appropriate personal protective equipment, including a dust mask (N95), eyeshields, and gloves, should be used. Handle in a well-ventilated area.
How is this product packed and shipped?
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Tech Serve Solutions ensures secure and appropriate packaging for domestic and international export, adhering to all relevant shipping regulations for chemical substances.
How can I request a sample or quote?
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To request a sample or obtain a quote for 6-Chloro-3-pyridineboronic acid pinacol ester, please contact our sales department via the website or by phone.
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