5′-Deoxy-5′-(methylthio)adenosine

CAS 2457-80-9C11H15N5O3SBiochemicals & Reagents

5′-Deoxy-5′-(methylthio)adenosine (CAS: 2457-80-9; Formula: C11H15N5O3S) is a biochemical reagent with a molecular weight of 297.33 g/mol. This nucleoside analog is instrumental in research involving enzyme kinetics and pathways, particularly in the study of 5′-methylthioadenosine phosphorylase (MTAP) and bacterial quorum sensing systems. It serves as a substrate for MTAP, an enzyme linked to tumor suppression, and is involved in investigations of bacterial signaling mechanisms.

IUPAC: MTA,Methylthioadenosine
Synonyms: MTAMethylthioadenosine

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5′-Deoxy-5′-(methylthio)adenosine (C11H15N5O3S) — chemical structure, CAS 2457-80-9; Life Science, fine chemical supplied by Tech Serve Solutions

Bioactive Small MoleculesBiochemicals and ReagentsCell BiologyD-DIFEpigeneticsMolecular BiologyNucleoside AnalogsNucleosidesNucleotidesOligonucleotides

01 /Applications

Enzyme Studies

Serves as a substrate for investigating the kinetics and specificity of 5′-methylthioadenosine phosphorylase (MTAP, EC2.4.2.28), an enzyme implicated in the S-adenosylmethionine and methionine salvage pathways.

Bacterial Quorum Sensing Research

Used in studies focusing on bacterial quorum sensing pathways, including investigations into enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).

Epigenetic Research

Relevant in the field of epigenetics, particularly for studies involving histone methylation and protein arginine methyltransferase (PRMT) modulators.

Biochemical Research

A valuable reagent for general biochemical research, cell biology studies, and the investigation of nucleoside analogs and their biological functions.

02 /Properties

Molecular weight	297.33
Empirical formula	C11H15N5O3S
Storage temperature	−20°C
Application	5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

Warning

Hazard statements

H302Harmful if swallowed

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2457-80-9

MDL number

MFCD00010533

PubChem substance

24893915

Beilstein registry

42420

05 /Additional specifications

Gene Information	human ... ADORA2B(136), ADORA3(140)mouse ... Mtap(66902)rat ... Adora1(29290), Adora2a(25369)

06 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

07 /Frequently asked questions

What is 5′-Deoxy-5′-(methylthio)adenosine used for?

5′-Deoxy-5′-(methylthio)adenosine is primarily used as a substrate in enzymatic studies, particularly for 5′-methylthioadenosine phosphorylase (MTAP) and in research on bacterial quorum sensing pathways. It is also relevant in epigenetic and molecular biology research.

What are the CAS number and molecular formula for 5′-Deoxy-5′-(methylthio)adenosine?

The CAS number is 2457-80-9, and the molecular formula is C11H15N5O3S.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies this product for research purposes. The specific grade and purity are detailed on the product's Certificate of Analysis. We do not represent this product as USP, BP, or EP grade.

What are the safety precautions for handling 5′-Deoxy-5′-(methylthio)adenosine?

This compound is classified with a 'Warning' signal word and carries hazard statement H302 (Harmful if swallowed). Recommended personal protective equipment includes eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter.

How is 5′-Deoxy-5′-(methylthio)adenosine packed, shipped, and exported?

Products are typically packed in appropriate containers for chemical stability and safety. We export globally, adhering to all relevant shipping and customs regulations.