5′-O-Tritylthymidine
5′-O-Tritylthymidine (CAS 7791-71-1), with the molecular formula C29H28N2O5 and a molecular weight of 484.54 g/mol, is a protected nucleoside analogue. It is primarily utilised in oligonucleotide synthesis and related biochemical research applications where selective protection of the 5'-hydroxyl group is required. Its structure facilitates controlled coupling reactions in the construction of DNA and RNA strands.
Oligonucleotide Synthesis
This compound serves as a crucial building block in the automated synthesis of DNA and RNA strands. The trityl group acts as a protecting group for the 5'-hydroxyl, enabling regioselective phosphoramidite chemistry.
Biochemical Research
Used in various research settings for developing modified nucleosides and nucleotides. It facilitates studies in molecular biology, diagnostics, and therapeutic development where precise chemical modifications are necessary.
Protecting Group Chemistry
The acid-labile trityl protecting group allows for orthogonal deprotection strategies in complex organic synthesis involving nucleosides.
| Molecular weight | 484.54 |
|---|---|
| Empirical formula | C29H28N2O5 |
| Assay | ~98% |
| Storage temperature | −20°C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 5′-O-Tritylthymidine used for?
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5′-O-Tritylthymidine is primarily used as a protected building block in oligonucleotide synthesis and for general biochemical research requiring selective protection of the 5'-hydroxyl group of thymidine.
What are the CAS number and molecular formula for 5′-O-Tritylthymidine?
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The CAS number is 7791-71-1, and the molecular formula is C29H28N2O5.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 5′-O-Tritylthymidine with an assay of approximately 98%. This product is not represented as USP, BP, EP, or any other pharmacopoeia grade; it is suitable for research and laboratory use.
How should 5′-O-Tritylthymidine be handled and stored?
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Handle with appropriate personal protective equipment, including eyeshields and gloves. A respirator filter (type N95 or P1) is recommended. Store at -20°C. This compound is classified under WGK Germany 3, indicating a high hazard.
Is 5′-O-Tritylthymidine a controlled substance?
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The provided data does not indicate that 5′-O-Tritylthymidine is a controlled substance.
How is 5′-O-Tritylthymidine packed and shipped?
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Products are carefully packed according to industry best practices for stability and safety during transit. Tech Serve Solutions is experienced in exporting chemicals globally.
How can I request a sample or a quote for 5′-O-Tritylthymidine?
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Please contact our sales team via the website or direct email to request a quotation or discuss sample availability.
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