4-(tert-Butyldimethylsilyloxy)cyclohexanone
4-(tert-Butyldimethylsilyloxy)cyclohexanone (CAS 55145-45-4, C12H24O2Si) is a versatile organic building block with a molecular weight of 228.40 g/mol. This silyl-protected cyclohexanone derivative is valuable in multi-step organic synthesis, offering a protected ketone functionality for selective reactions. It serves as a key intermediate in the preparation of more complex molecules within pharmaceutical and fine chemical research and development.
Protecting Group Chemistry
The tert-butyldimethylsilyl (TBS) group protects the hydroxyl functionality on the cyclohexanone ring, allowing for selective transformations at the carbonyl group. This protection can be removed under specific conditions when needed.
Intermediate in Pharmaceutical Synthesis
This compound acts as a crucial intermediate in the synthesis of active pharmaceutical ingredients (APIs) and their precursors, enabling the construction of complex molecular architectures.
Organic Synthesis Building Block
As a functionalised cyclic ketone, it is employed in various carbon-carbon bond-forming reactions and functional group interconversions in academic and industrial research.
Fine Chemical Manufacturing
Used in the production of specialised fine chemicals where precise control over functional group reactivity is required, contributing to the development of novel materials.
| Molecular weight | 228.40 |
|---|---|
| Empirical formula | C12H24O2Si |
| Assay | 97% |
| Boiling point | 85 °C/1 mmHg(lit.) |
| Density | 0.909 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.4530(lit.) |
| Protective equipment | Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | >110 °C / >230 °F |
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-(tert-Butyldimethylsilyloxy)cyclohexanone used for?
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4-(tert-Butyldimethylsilyloxy)cyclohexanone is primarily used as a building block in organic synthesis, particularly in multi-step syntheses within pharmaceutical and fine chemical research. It functions as a protected ketone intermediate.
What are the CAS number and formula for 4-(tert-Butyldimethylsilyloxy)cyclohexanone?
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The CAS number is 55145-45-4, and the molecular formula is C12H24O2Si.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-(tert-Butyldimethylsilyloxy)cyclohexanone with a minimum assay of 97%. This product is typically considered a technical or research grade material and is not represented as USP, BP, or EP grade.
How should 4-(tert-Butyldimethylsilyloxy)cyclohexanone be handled?
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When handling 4-(tert-Butyldimethylsilyloxy)cyclohexanone, it is essential to use appropriate personal protective equipment, including eyeshields and gloves. A half-mask respirator (EU or US) or a multi-purpose combination respirator cartridge (US) may be necessary. The flash point is greater than 110 °C (230 °F).
How is this chemical packed and exported?
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Tech Serve Solutions professionally packs and exports chemicals globally, adhering to all necessary regulations for safe transport and handling.
How can I request a quote or sample?
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To request a quote or sample of 4-(tert-Butyldimethylsilyloxy)cyclohexanone, please use the contact form on our website or contact our sales department directly.
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