Boc-Glu(OtBu)-OH

CAS 13726-84-6(CH3)3COCOCH2CH2CH(COOH)NHCOOC(CH3)3Chemical Synthesis

Boc-Glu(OtBu)-OH (CAS 13726-84-6) is a protected derivative of L-glutamic acid, featuring tert-butyloxycarbonyl (Boc) protection on the amine group and tert-butyl ester protection on the side-chain carboxyl group. With a molecular weight of 303.35, this compound is crucial in peptide synthesis and organic chemistry. It facilitates controlled amino acid coupling, preventing side reactions and ensuring the integrity of the growing peptide chain in complex syntheses.

IUPAC: Boc-L-glutamic acid 5-tert-butyl ester
Synonyms: Boc-L-glutamic acid 5-tert-butyl ester

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Boc-Glu(OtBu)-OH ((CH3)3COCOCH2CH2CH(COOH)NHCOOC(CH3)3) — chemical structure, CAS 13726-84-6; Chemistry, fine chemical supplied by Tech Serve Solutions

Amino Acid DerivativesChemical BiologyChemical SynthesisGlutamic AcidPeptide Chemistry

01 /Applications

Peptide Synthesis

Boc-Glu(OtBu)-OH is widely utilized as a building block in solid-phase and solution-phase peptide synthesis. The orthogonal protecting groups allow for selective deprotection and coupling steps, enabling the construction of complex peptide sequences.

Chemical Synthesis

This derivative serves as a versatile intermediate in the synthesis of various organic molecules. Its protected functional groups enable regioselective reactions, making it valuable in the development of novel compounds and pharmaceutical intermediates.

Chemical Biology Research

Used in the development of modified peptides or peptidomimetics for probing biological pathways. The protected glutamic acid moiety can be incorporated into biomolecules to study protein-ligand interactions or enzymatic activity.

02 /Properties

Molecular weight	303.35
Linear formula	(CH3)3COCOCH2CH2CH(COOH)NHCOOC(CH3)3
Assay	≥99.0% (sum of enantiomers, TLC)
Optical activity	[α]20/D −9.5±1°, c = 1% in methanol
Storage temperature	2-8°C
Melting point	102-105 °C

03 /Safety & handling

Protective equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Water hazard class (WGK, DE)	3

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

13726-84-6

MDL number

MFCD00038257

Beilstein registry

2149791

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is Boc-Glu(OtBu)-OH used for?

Boc-Glu(OtBu)-OH is primarily used as a protected amino acid building block in peptide synthesis and as an intermediate in organic and chemical biology research.

What is the CAS number and formula for Boc-Glu(OtBu)-OH?

The CAS number for Boc-Glu(OtBu)-OH is 13726-84-6. Its linear formula is (CH3)3COCOCH2CH2CH(COOH)NHCOOC(CH3)3.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies Boc-Glu(OtBu)-OH with an assay of ≥99.0% (sum of enantiomers, by TLC). We do not represent this product as USP, EP, or BP grade.

How should Boc-Glu(OtBu)-OH be handled and stored?

Handling requires appropriate personal protective equipment, including eyeshields and gloves, and potentially a respirator filter. Store at 2-8°C.

Is Boc-Glu(OtBu)-OH a controlled substance?

The provided data does not indicate that Boc-Glu(OtBu)-OH is a controlled substance.

How can I request a sample or quote for Boc-Glu(OtBu)-OH?

Please contact our sales team through the website or by phone to request a sample or a quotation for Boc-Glu(OtBu)-OH.

How is Boc-Glu(OtBu)-OH shipped and exported?

Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals. Specific shipping and export details for Boc-Glu(OtBu)-OH can be discussed with our logistics team.