4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate
4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate (CAS: 80149-80-0; C12H17NO5Si) is a versatile reagent with a molecular weight of 283.35 g/mol. It serves as a valuable protecting group in organic synthesis, particularly for amines. Its chemical structure facilitates controlled deprotection under specific conditions, making it useful in multi-step syntheses and the preparation of complex molecules within chemical biology and peptide chemistry.
- IUPAC
- 2-(Trimethylsilyl)ethyl 4-nitrophenyl carbonate,TEOC-ONp
Amine Protection
This compound acts as an effective reagent for introducing the 2-(trimethylsilyl)ethyl (TEOC) protecting group onto amine functionalities. The TEOC group offers orthogonal deprotection strategies, valuable in complex syntheses.
Peptide Synthesis
In peptide chemistry, it can be employed to protect amino groups during solid-phase or solution-phase synthesis. This ensures selective coupling reactions and prevents unwanted side reactions.
Organic Synthesis
As a synthetic reagent, it enables chemists to selectively functionalise molecules. Its application spans various areas of organic synthesis requiring precise control over reactive groups.
Chemical Biology Research
It can be utilised in studies involving modified biomolecules, where controlled protection and deprotection of amine groups are essential for experimental design and execution.
| Molecular weight | 283.35 |
|---|---|
| Empirical formula | C12H17NO5Si |
| Assay | ≥95.0% (NMR) |
| Storage temperature | 2-8°C |
| Melting point | 35-40 °C |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate used for?
+
4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate is primarily used as a protecting group for amines in organic synthesis, including peptide chemistry and chemical biology research. It allows for the controlled introduction and subsequent removal of the 2-(trimethylsilyl)ethyl (TEOC) group.
What are the CAS number and formula for this compound?
+
The CAS number is 80149-80-0 and the empirical formula is C12H17NO5Si.
What grade and purity does Tech Serve Solutions supply?
+
Tech Serve Solutions supplies this chemical with an assay of ≥95.0% as determined by NMR. We do not represent this product as meeting USP, BP, EP, or other pharmacopoeia standards.
What are the safety and handling precautions for 4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate?
+
This compound requires careful handling. Recommended personal protective equipment includes eyeshields, gloves, and a type N95 (US) or type P1 (EN143) respirator filter. Refer to the safety data sheet for comprehensive hazard information.
How is this chemical shipped and stored?
+
It should be stored at 2-8°C. TSS exports chemicals globally; please contact us for specific shipping and handling details pertaining to your region.
How can I request a sample or a quote for 4-Nitrophenyl 2-(trimethylsilyl)ethyl carbonate?
+
You can request a sample or a quotation by contacting our sales department through the website or by calling us directly.
▶ Related products
1-(2-Fluorobenzyl)piperazine
C11H15FN2
Chemical Synthesis
1-(2-Fluorophenyl)biguanide hydrochloride
Chemical Synthesis
1-(2-Fluorophenyl)cyclopropanecarboxylic acid
C10H9FO2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine
C10H13FN2
Chemical Synthesis
1-(2-Fluorophenyl)piperazine monohydrochloride
C10H13FN2 · HCl
Chemical Synthesis
1-(2-Furoyl)-1H-benzotriazole
C11H7N3O2
Chemical Synthesis
1-(2-Furoyl)piperazine
C9H12N2O2
Chemical Synthesis
1-(2-Hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione
Chemical Synthesis
▶ Explore more
3-Methyl-1,5-di-p-tolyl-1,4-pentazadiene
Chemical Synthesis
3-Methyl-1,5-pentanediol
Chemical Synthesis
3-Methyl-1-(2-methylphenyl)-1H-pyrazol-5-amine
C11H13N3
Chemical Synthesis
3-Methyl-1-(3′-sulfoamidophenyl)-5-pyrazolone
C10H11N3O3S
Chemical Synthesis