4-Nitrophenyl chloroformate
4-Nitrophenyl chloroformate (CAS: 7693-46-1) is a chemical compound with the linear formula ClCOOC6H4NO2 and a molecular weight of 201.56 g/mol. This reagent is primarily used in chemical synthesis, notably in the preparation of modified dextrans. It serves as a valuable intermediate and coupling agent in various organic transformations, contributing to advancements in chemical biology and peptide chemistry. Tech Serve Solutions supplies this compound for research and development purposes.
- IUPAC
- Chloroformic acid 4-nitrophenyl ester
- Synonyms
- Chloroformic acid 4-nitrophenyl ester
Poly(oxyethylene) Modified Dextrans
4-Nitrophenyl chloroformate is employed in the synthesis of poly(oxyethylene) modified dextrans, a process crucial for developing advanced biomaterials and drug delivery systems. This application highlights its utility in polymer chemistry and bioconjugation.
Peptide Synthesis
As an active ester, it can function as a coupling reagent in peptide synthesis. Its reactivity allows for the formation of peptide bonds, contributing to the construction of complex peptides and peptidomimetics.
Chemical Biology Reagent
This compound serves as a useful reagent in chemical biology research. Its electrophilic nature enables derivatization of biomolecules, facilitating studies in molecular interactions and biological pathways.
Organic Synthesis Intermediate
4-Nitrophenyl chloroformate acts as a versatile intermediate in general organic synthesis. It is employed to introduce the 4-nitrophenoxycarbonyl group into various molecules, enabling further functionalisation and modification.
| Molecular weight | 201.56 |
|---|---|
| Linear formula | ClCO2C6H4NO2 |
| Assay | 96% |
| Boiling point | 159-162 °C/19 mmHg(lit.) |
| Storage temperature | 2-8°C |
| Application | Employed in the preparation of poly(oxyethylene) modified dextrans.1 |
| Melting point | 77-79 °C(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 3261 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-36/37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4-Nitrophenyl chloroformate used for?
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4-Nitrophenyl chloroformate is used in the preparation of poly(oxyethylene) modified dextrans and as a coupling agent or intermediate in peptide and general organic synthesis, as well as in chemical biology research.
What is the CAS number and formula for 4-Nitrophenyl chloroformate?
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The CAS number is 7693-46-1 and the linear formula is ClCOOC6H4NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4-Nitrophenyl chloroformate with an assay of 96%. TSS does not represent this product as USP, BP, EP, or other pharmacopoeia grades.
How should 4-Nitrophenyl chloroformate be handled safely?
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4-Nitrophenyl chloroformate is corrosive and may cause respiratory irritation. Handle with appropriate personal protective equipment, including eyeshields, face shields, gloves, and respiratory protection suitable for corrosive and irritating vapours and dust. Ensure adequate ventilation.
How is 4-Nitrophenyl chloroformate packed, shipped, and exported?
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4-Nitrophenyl chloroformate is packed according to UN 3261, 8 / PGII regulations for safe transport. Tech Serve Solutions has extensive experience in exporting fine chemicals globally.
How can I request a sample or quote for 4-Nitrophenyl chloroformate?
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To request a sample or a quote for 4-Nitrophenyl chloroformate, please contact our sales team via the website or direct email.
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