4,6-Dimethoxy-3-methylindole
4,6-Dimethoxy-3-methylindole (CAS 74973-30-1) is a heterocyclic organic compound with the molecular formula C11H13NO2 and a molecular weight of 191.23 g/mol. This indole derivative serves as a valuable building block in organic synthesis. It is particularly utilised in acid-catalyzed reactions, and as a precursor for the synthesis of complex fused ring systems such as pyrrolo[1,2-a]indoles and indolo[2,3-c]quinolines. Further applications include nitration and oxidative dimerisation.
- IUPAC
- 4,6-Dimethoxy-3-methyl-1H-indole
- Synonyms
- 4,6-Dimethoxy-3-methylindole4,6-Dimethoxy-3-methyl-1H-indole
Precursor for Pyrrolo[1,2-a]indoles
4,6-Dimethoxy-3-methylindole is employed in synthetic routes leading to the formation of pyrrolo[1,2-a]indole derivatives. These compounds are of interest in medicinal chemistry and materials science.
Synthesis of Indolo[2,3-c]quinolines
This indole derivative acts as a key intermediate in the construction of indolo[2,3-c]quinoline ring systems. These heterocyclic scaffolds are explored for potential pharmaceutical applications.
Reactant in Acid-Catalyzed Reactions
The compound participates in acid-catalyzed reactions, specifically with ketones, acting as a nucleophilic partner in condensation and cyclisation processes.
Nitration and Oxidative Dimerisation
4,6-Dimethoxy-3-methylindole undergoes nitration and oxidative dimerisation reactions when treated with nitric acid, leading to functionalised indole products.
| Molecular weight | 191.23 |
|---|---|
| Empirical formula | C11H13NO2 |
| Assay | 97% |
| Application | Reactant for:• Acid-catalyzed reactions with ketones1• Synthesis of pyrrolo[1,2-a]indoles2• Synthesis of indolo[2,3-c]quinolines3• Nitration and oxidative dimerization reactions with nitric acid4 |
| Melting point | 83-86 °C |
Hazard statements
- H302Harmful if swallowed
- H315Causes skin irritation
- H318Causes serious eye damage
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 22-37/38-41 |
| Safety statements (S) | 26-36/37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 4,6-Dimethoxy-3-methylindole used for?
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4,6-Dimethoxy-3-methylindole is used as a reactant in acid-catalyzed reactions with ketones, and as a building block for the synthesis of pyrrolo[1,2-a]indoles and indolo[2,3-c]quinolines. It also participates in nitration and oxidative dimerisation reactions.
What is the CAS number and molecular formula for 4,6-Dimethoxy-3-methylindole?
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The CAS number is 74973-30-1, and the molecular formula is C11H13NO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 4,6-Dimethoxy-3-methylindole with a minimum assay of 97%. We do not represent this product as USP, BP, or EP grade; it is intended for research and chemical synthesis purposes.
How should 4,6-Dimethoxy-3-methylindole be handled?
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4,6-Dimethoxy-3-methylindole is classified as a Danger substance. It is harmful if swallowed (H302), causes skin irritation (H315), causes serious eye damage (H318), and may cause respiratory irritation (H335). Always handle with appropriate personal protective equipment, including a dust mask type N95, eyeshields, face shield, and gloves, in a well-ventilated area.
Is 4,6-Dimethoxy-3-methylindole a controlled substance?
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Based on the provided data, 4,6-Dimethoxy-3-methylindole is not listed as a controlled substance.
How is this chemical shipped and exported?
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Tech Serve Solutions specialises in the global supply and export of fine chemicals. Please contact us for specific shipping and export details regarding 4,6-Dimethoxy-3-methylindole to your region.
How can I request a sample or quote for 4,6-Dimethoxy-3-methylindole?
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To request a sample or a quote for 4,6-Dimethoxy-3-methylindole, please use the contact form on our website or reach out to our sales department directly.
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