3-(Trifluoromethyl)cinnamic acid, predominantly trans
3-(Trifluoromethyl)cinnamic acid, predominantly trans (CAS: 779-89-5) is a fluorinated organic compound with the linear formula CF<sub>3</sub>C<sub>6</sub>H<sub>4</sub>CH=CHCO<sub>2</sub>H and a molecular weight of 216.16 g/mol. It serves as a valuable building block in organic synthesis, particularly within the pharmaceutical industry. Notably, it has been employed in the synthesis of cinacalcet, a calcimimetic drug.
- Synonyms
- 3-(Trifluoromethyl)cinnamic acid, predominantly transCF3C6H4CH=CHCO2H
Pharmaceutical Synthesis Intermediate
This compound has been utilized as a key intermediate in the synthesis of active pharmaceutical ingredients. A specific documented application includes its use in the preparation of cinacalcet.
Organic Building Block
As a carboxylic acid with a trifluoromethyl group and a cinnamic acid backbone, it offers reactive sites for various chemical transformations. It is a useful reagent for introducing fluorinated aromatic moieties into organic structures.
Chemical Research and Development
Its unique structure makes it a subject of interest in academic and industrial research for developing novel compounds and exploring new synthetic methodologies.
| Molecular weight | 216.16 |
|---|---|
| Linear formula | CF3C6H4CH=CHCO2H |
| Assay | 98% |
| Application | 3-(Trifluoromethyl)cinnamic acid was used in the synthesis of cinacalcet1. |
| Melting point | 135-137 °C(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-37/39 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethyl)cinnamic acid predominantly trans used for?
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3-(Trifluoromethyl)cinnamic acid, predominantly trans is used as a building block in organic synthesis, notably in the preparation of cinacalcet and for introducing trifluoromethylated phenyl groups in chemical research.
What are the CAS number and formula for this chemical?
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The CAS number is 779-89-5, and its linear formula is CF3C6H4CH=CHCO2H.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical with an assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 3-(Trifluoromethyl)cinnamic acid be handled?
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This compound is a warning hazard, causing skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Appropriate personal protective equipment includes a dust mask type N95 (US), eyeshields, and gloves. Ensure adequate ventilation and avoid breathing dust.
How is this product shipped and exported?
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Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, pharmaceutical intermediates, and laboratory reagents, shipping worldwide.
How can I request a sample or quote?
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Please contact our sales team via the website to request a sample or a quotation for 3-(Trifluoromethyl)cinnamic acid.
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