3-(Trifluoromethyl)benzylzinc chloride solution
3-(Trifluoromethyl)benzylzinc chloride solution (CAS: 480438-42-4) is an organozinc halide reagent, identified by the linear formula F₃CC₆H₄CH₂ZnCl and a molar mass of 259.97 g/mol. Supplied as a 0.5 M solution in Tetrahydrofuran (THF), this compound is valuable in organic synthesis for forming new carbon-carbon bonds through cross-coupling reactions. Its utility is particularly noted in the preparation of complex organic molecules and pharmaceutical intermediates.
Cross-Coupling Reactions
This organozinc reagent is extensively employed in Negishi and related cross-coupling reactions for the synthesis of biaryls and other complex organic structures. It facilitates the formation of C-C bonds with high efficiency.
Pharmaceutical Intermediate Synthesis
It serves as a key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and advanced intermediates. The trifluoromethylbenzyl moiety can be incorporated into drug candidates.
Organometallic Chemistry Research
As a well-defined organozinc halide, it is utilised in academic and industrial research laboratories for exploring new synthetic methodologies and reaction mechanisms involving organometallic species.
| Molecular weight | 259.97 |
|---|---|
| Linear formula | F3CC6H4CH2ZnCl |
| Boiling point | 65 °C |
| Density | 0.986 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2056 3 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethyl)benzylzinc chloride solution used for?
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This compound is primarily used in organic synthesis for cross-coupling reactions, particularly in the preparation of pharmaceutical intermediates and complex organic molecules.
What is the CAS number and formula for 3-(Trifluoromethyl)benzylzinc chloride solution?
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The CAS number is 480438-42-4 and the linear formula is F₃CC₆H₄CH₂ZnCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this reagent as a 0.5 M solution in THF. We do not claim USP, BP, or EP grade unless explicitly stated, and it should be treated as a research or technical grade chemical for laboratory use.
How should 3-(Trifluoromethyl)benzylzinc chloride solution be handled safely?
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This solution is highly flammable (flash point -17 °C) and can form explosive peroxides. It is an irritant to the eyes and respiratory system, and is suspected of causing cancer. Handle with appropriate personal protective equipment in a well-ventilated area, away from ignition sources, and store under recommended refrigeration (2-8°C).
How is this chemical packed, shipped, and exported?
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This chemical is packed and shipped according to international regulations for hazardous materials, including UN 2056, Class 3, Packing Group II. Tech Serve Solutions is a global supplier and exporter, experienced in handling and shipping sensitive reagents worldwide.
How can I request a sample or quote?
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To request a sample or a quotation for 3-(Trifluoromethyl)benzylzinc chloride solution, please contact our sales department through the website or by phone, providing your specific requirements.
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