3-(Trifluoromethyl)benzyl chloride
3-(Trifluoromethyl)benzyl chloride (CAS: 705-29-3) is a halogenated hydrocarbon and an organic building block with the molecular formula CF3C6H4CH2Cl and a molecular weight of 194.58 g/mol. This compound serves as a valuable intermediate in chemical synthesis. It is primarily utilised in the creation of more complex organic molecules, particularly within pharmaceutical research and development, owing to its reactive benzyl chloride functionality and the electron-withdrawing trifluoromethyl group.
- IUPAC
- α′-Chloro-α,α,α-trifluoro-m-xylene,3-(Chloromethyl)benzotrifluoride
Organic Synthesis Intermediate
This compound is frequently employed as a key building block in the synthesis of diverse organic molecules. Its benzyl chloride moiety allows for facile nucleophilic substitution reactions, enabling the introduction of the 3-(trifluoromethyl)benzyl group into various structures.
Pharmaceutical Research
3-(Trifluoromethyl)benzyl chloride is utilised in the preparation of novel compounds investigated for pharmaceutical applications. Its structure is incorporated into potential drug candidates, contributing to their pharmacokinetic and pharmacodynamic properties.
Material Science
The compound may find application in the development of specialised materials where the trifluoromethyl group imparts unique electronic or physical properties, such as in the synthesis of functional polymers or advanced organic materials.
| Molecular weight | 194.58 |
|---|---|
| Linear formula | CF3C6H4CH2Cl |
| Assay | 97% |
| Density | 1.254 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.464(lit.) |
| Application | 3-(Trifluoromethyl)benzyl chloride was used in the synthesis of 4-nitro-3-trifluoromethyl-[N-(4-hydroxyphenyl)]benzamide1. |
Hazard statements
- H226Flammable liquid and vapour
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 48 °C / 118.4 °F |
| Transport (UN / ADR) | UN 2920 3(8) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 10-34 |
| Safety statements (S) | 16-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethyl)benzyl chloride used for?
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3-(Trifluoromethyl)benzyl chloride is primarily used as an intermediate in organic synthesis, particularly in the development of pharmaceutical compounds and potentially in material science applications. It serves as a building block for introducing the 3-(trifluoromethyl)benzyl moiety into larger molecular structures.
What are the CAS number and chemical formula for 3-(Trifluoromethyl)benzyl chloride?
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The CAS number for 3-(Trifluoromethyl)benzyl chloride is 705-29-3, and its chemical formula is CF3C6H4CH2Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions typically supplies 3-(Trifluoromethyl)benzyl chloride with an assay of 97%. This product is generally supplied for research and laboratory use. TSS does not represent this product as USP, BP, or EP grade.
How should 3-(Trifluoromethyl)benzyl chloride be handled safely?
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3-(Trifluoromethyl)benzyl chloride is classified as a Danger material due to flammability (H226) and causing severe skin burns and eye damage (H314). Handle with extreme caution, using appropriate personal protective equipment including gloves, eye protection (goggles and face shield), and respiratory protection (e.g., ABEK type filter). Ensure adequate ventilation and avoid ignition sources. Refer to the Safety Data Sheet for comprehensive handling instructions.
Is 3-(Trifluoromethyl)benzyl chloride a controlled substance?
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The provided data does not indicate that 3-(Trifluoromethyl)benzyl chloride is a controlled substance.
How is 3-(Trifluoromethyl)benzyl chloride shipped and exported?
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As an experienced global supplier, Tech Serve Solutions is proficient in exporting chemicals like 3-(Trifluoromethyl)benzyl chloride. It is shipped according to international regulations for hazardous materials, classified under UN 2920, Hazard Class 3 (flammable liquid) with subsidiary risk 8 (corrosive), Packing Group II.
How can I request a quote or sample for 3-(Trifluoromethyl)benzyl chloride?
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To request a quote or a sample of 3-(Trifluoromethyl)benzyl chloride, please contact our sales team through the website or by phone. Provide your contact details and the quantity required, and we will respond promptly.
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