3-(Trifluoromethyl)benzoyl chloride
3-(Trifluoromethyl)benzoyl chloride (CAS 2251-65-2) is a reactive organic compound with the linear formula CF3C6H4COCl and a molecular weight of 208.56 g/mol. As an acid halide and carbonyl compound, it serves as a valuable building block in organic synthesis. This chemical is primarily employed in the preparation of intermediates crucial for the development of specific pyrazolo[1,5-a]pyrimidine derivatives.
- IUPAC
- α,α,α-Trifluoro-m-toluoyl chloride
- Synonyms
- α,α,α-Trifluoro-m-toluoyl chloride
Synthesis of Pyrazolo[1,5-a]pyrimidines
3-(Trifluoromethyl)benzoyl chloride is utilised in the preparation of key intermediates. These intermediates are essential for the subsequent synthesis of C-2 and C-3 substituted pyrazolo[1,5-a]pyrimidines, a class of heterocyclic compounds with potential pharmaceutical applications.
Organic Building Block
As a functionalised aromatic compound, it acts as a versatile building block in organic chemistry. Its reactive acyl chloride group allows for facile derivatisation, enabling the construction of more complex molecular structures.
Chemical Synthesis Reagent
This compound is employed as a reagent in various chemical synthesis pathways. Its specific structure allows for the introduction of the 3-(trifluoromethyl)benzoyl moiety into target molecules, contributing to the development of novel compounds.
| Molecular weight | 208.56 |
|---|---|
| Linear formula | CF3C6H4COCl |
| Assay | 98% |
| Boiling point | 184-186 °C/750 mmHg(lit.) |
| Density | 1.383 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.477(lit.) |
| Application | 3-(Trifluoromethyl)benzoyl chloride has been used in the preparation of intermediates, required for synthesis of C-2 and C-3 substituted pyrazolo[1,5-a]pyrimidines1. |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 113 °C / 235.4 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34-37 |
| Safety statements (S) | 26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethyl)benzoyl chloride used for?
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3-(Trifluoromethyl)benzoyl chloride is primarily used as an intermediate in the synthesis of pyrazolo[1,5-a]pyrimidines and as a general building block in organic synthesis.
What are the CAS number and formula for 3-(Trifluoromethyl)benzoyl chloride?
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The CAS number is 2251-65-2, and its linear formula is CF3C6H4COCl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-(Trifluoromethyl)benzoyl chloride with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
How is 3-(Trifluoromethyl)benzoyl chloride handled and shipped?
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This compound is classified as corrosive and can cause severe skin burns and eye damage (H314). It is shipped in accordance with UN 3265, Class 8, Packing Group II regulations, requiring appropriate safety precautions and packaging.
How can I request a quote or sample?
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Please contact our sales department via the website or by phone to request a quotation or a product sample.
What are the GHS hazards associated with this chemical?
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The GHS symbol is GHS05, the signal word is Danger, and the primary hazard statement is H314 (Causes severe skin burns and eye damage). Appropriate personal protective equipment, including full-face protection and chemical-resistant gloves, is essential.
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