3,5-Dimethylaniline
3,5-Dimethylaniline (CAS: 108-69-0) is an organic compound with the linear formula (CH3)2C6H3NH2 and a molecular weight of 121.18 g/mol. Also known as 3,5-xylidine, this aromatic amine serves as a versatile building block in chemical synthesis. Its properties make it valuable in the creation of specialised materials, such as chiral packing for chromatography, contributing to advancements in analytical chemistry and material science.
- IUPAC
- 1-Amino-3,5-dimethylbenzene,3,5-Xylidine,5-Amino-m-xylene
- Synonyms
- (CH3)2C6H3NH23,5-Xylidine1-Amino-3,5-dimethylbenzene5-Amino-m-xylene

Chromatographic Material Synthesis
3,5-Dimethylaniline is utilised in the synthesis of chiral stationary phases for high-performance liquid chromatography (HPLC). These specialised materials are crucial for separating enantiomers and other chiral compounds.
Organic Synthesis Intermediate
As an aromatic amine, 3,5-dimethylaniline acts as a key intermediate in the construction of more complex organic molecules. Its structure allows for various derivatisation reactions essential in fine chemical and pharmaceutical research.
Research and Development
This compound is employed in research settings for exploring new synthetic routes and developing novel materials. Its availability as a building block facilitates innovation across different chemical disciplines.
| Molecular weight | 121.18 |
|---|---|
| Linear formula | (CH3)2C6H3NH2 |
| Assay | 98% |
| Boiling point | 104-105 °C/14 mmHg(lit.) |
| Density | 0.972 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.557(lit.) |
| Application | 3,5-Dimethylaniline was used in the synthesis of chiral packing materials for high performance liquid chromatography1. |
| Melting point | 7-9 °C |



Hazard statements
- H301Toxic if swallowed
- H311Toxic in contact with skin
- H331Toxic if inhaled
- H373May cause damage to organs through prolonged exposure
- H411Toxic to aquatic life with long-lasting effects
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P273Avoid release to the environment
- P280Wear protective gloves, clothing and eye/face protection
- P301IF SWALLOWED
- P311Call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 101 °C / 213.8 °F |
| Transport (UN / ADR) | UN 1711 6.1 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | T,N |
| Risk statements (R) | 23/24/25-33-51/53 |
| Safety statements (S) | 28-36/37-45-61 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3,5-Dimethylaniline used for?
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3,5-Dimethylaniline is primarily used as a building block in organic synthesis, notably in the preparation of chiral packing materials for high-performance liquid chromatography.
What is the CAS number and formula for 3,5-Dimethylaniline?
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The CAS number for 3,5-Dimethylaniline is 108-69-0, and its linear formula is (CH3)2C6H3NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3,5-Dimethylaniline with a minimum assay of 98%. We do not represent this product as USP, BP, EP, or any other pharmacopoeia grade.
How should 3,5-Dimethylaniline be handled safely?
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3,5-Dimethylaniline is classified as toxic and harmful to aquatic life. Handle with appropriate personal protective equipment, including eyeshields, gloves, and a full-face or combination respirator. Ensure adequate ventilation and avoid release into the environment.
How is 3,5-Dimethylaniline packed and shipped?
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3,5-Dimethylaniline is packed and shipped according to international regulations for hazardous materials. As a global supplier and exporter, TSS ensures compliance with all relevant shipping and handling requirements.
How can I request a quote or sample for 3,5-Dimethylaniline?
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To request a quote or sample for 3,5-Dimethylaniline, please contact our sales department through the website or by phone. Specify the quantity and any particular requirements you may have.
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