Methyl 4-methoxyacetoacetate
Methyl 4-methoxyacetoacetate (CAS 41051-15-4), with the molecular formula C6H10O4 and a molar mass of 146.14 g/mol, is a versatile organic compound. It functions as a valuable building block in chemical synthesis, particularly within ester and carbonyl compound classes. Its utility is demonstrated in generating diverse dihydropyrimidine derivatives through multi-component reactions, making it a useful intermediate for researchers and chemists.
Dihydropyrimidine Synthesis
Methyl 4-methoxyacetoacetate serves as a key beta-ketoester component in the Biginelli cyclocondensation reaction. This one-pot, three-component synthesis allows for the efficient generation of a library of functionalized dihydropyrimidine derivatives.
Organic Synthesis Intermediate
As a functionalised ester and carbonyl compound, it is employed in various organic synthesis pathways. Its structure facilitates the introduction of specific chemical moieties in complex molecule construction.
Research and Development
This compound is utilised in R&D settings for exploring new synthetic methodologies and creating novel chemical entities for potential applications in medicinal chemistry and materials science.
| Molecular weight | 146.14 |
|---|---|
| Linear formula | CH3OCH2COCH2COOCH3 |
| Assay | 97% |
| Boiling point | 89 °C/8.5 mmHg(lit.) |
| Density | 1.129 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.431(lit.) |
| Application | Methyl 4-methoxyacetoacetate has been used in generation of a small focused library of diversely functionalized dihydropyrimidine derivatives via one-pot three-component Biginelli cyclocondensation of β-ketoesters, aldehydes and (thio)ureas1. |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 87 °C / 188.6 °F |
| Transport (UN / ADR) | NA 1993 / PGIII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Methyl 4-methoxyacetoacetate used for?
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Methyl 4-methoxyacetoacetate (CAS 41051-15-4) is primarily used as a building block in organic synthesis, notably for the preparation of dihydropyrimidine derivatives via the Biginelli reaction.
What is the CAS number and chemical formula for Methyl 4-methoxyacetoacetate?
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The CAS number is 41051-15-4 and its linear formula is CH3OCH2COCH2COOCH3.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Methyl 4-methoxyacetoacetate with a minimum assay of 97%. This product is supplied for research and laboratory use and is not represented as USP, BP, EP, or other pharmacopoeial grades.
How should Methyl 4-methoxyacetoacetate be handled safely?
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Methyl 4-methoxyacetoacetate is classified with Warning signal word and hazards H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation). Handle with appropriate personal protective equipment, including eyeshields and gloves, and ensure adequate ventilation. Consult the Safety Data Sheet for full details.
Is this chemical a controlled substance?
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Based on the provided data, Methyl 4-methoxyacetoacetate (CAS 41051-15-4) is not indicated as a controlled substance.
How is Methyl 4-methoxyacetoacetate packaged and exported?
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Tech Serve Solutions packages and exports chemicals according to international shipping regulations, including appropriate hazard labelling and documentation for safe transport.
How can I request a quote or sample?
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To request a quote or sample of Methyl 4-methoxyacetoacetate, please contact the Tech Serve Solutions sales team through the website or direct contact information provided.
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