3-(Trifluoromethoxy)phenylboronic acid
3-(Trifluoromethoxy)phenylboronic acid (CAS: 179113-90-7) is an organoboron compound with the formula CF3OC6H4B(OH)2 and a molecular weight of 205.93 g/mol. This aryl boronic acid serves as a valuable precursor in organic synthesis, primarily for constructing complex molecules. Its applications span the development of novel pharmaceuticals, particularly in areas like pain management and metabolic disorders.
- IUPAC
- 3-Trifluoromethoxybenzeneboronic acid
- Synonyms
- 3-Trifluoromethoxybenzeneboronic acid
Pharmaceutical Intermediate
This compound is a key building block in the synthesis of various biologically active molecules. It has been employed in the development of potential therapeutics targeting conditions such as pain, obesity, and cardiovascular diseases.
Drug Discovery
Utilised in the creation of novel chemical entities for drug discovery programs. Examples include its use in synthesising P2X7 antagonists and aldosterone synthase inhibitors.
Organic Synthesis Reagent
As an aryl boronic acid, it is a versatile reagent for cross-coupling reactions, enabling the formation of carbon-carbon bonds for creating complex organic structures.
| Molecular weight | 205.93 |
|---|---|
| Linear formula | CF3OC6H4B(OH)2 |
| Application | Precursor commonly used in the synthesis of biologically active compounds including:• Multisubstituted purines for use as P2X7 antagonists in the treatment of pain1• Heteroaryl substituted tetrahydropyrroloijquinolinone derivatives as aldosterone synthase inhibitors2• Fluorohydroquinolineethanol as a CETP inhibitor3• Biaryl amides with muscarinic acetylcholine receptor subtype M1 agonist activity4• C2-aryl pyrrolobenzodiasepine antitumor agents5• Piperazine-bisamide for obesity treatments6 |
| Melting point | 84-89 °C(lit.) |
| Protective equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
|---|---|
| Water hazard class (WGK, DE) | 3 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Trifluoromethoxy)phenylboronic acid used for?
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3-(Trifluoromethoxy)phenylboronic acid is used as a precursor in the synthesis of biologically active compounds and in drug discovery, particularly for developing pharmaceuticals targeting pain, metabolic disorders, and other therapeutic areas.
What is the CAS number and chemical formula for this compound?
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The CAS number is 179113-90-7 and the chemical formula is CF3OC6H4B(OH)2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this chemical for research and laboratory use. The specific assay and purity are detailed in the product's Certificate of Analysis, and it is not represented as USP, BP, or EP grade.
What are the safety and handling considerations for 3-(Trifluoromethoxy)phenylboronic acid?
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This compound requires appropriate personal protective equipment, including eyeshields and gloves. Respiratory protection, such as a type N95 (US) or type P1 (EN143) respirator filter, is recommended. Refer to the Safety Data Sheet for comprehensive handling information. It is classified with WGK Germany 3.
How is this chemical shipped and exported?
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Tech Serve Solutions is an experienced global supplier and exporter of fine chemicals, adhering to all necessary regulations for safe and compliant international shipping.
How can I request a sample or a quote?
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Please contact our sales team directly through our website or via the provided contact details to request a sample or a quotation for 3-(Trifluoromethoxy)phenylboronic acid.
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