Naphthol AS-OL phosphate
Naphthol AS-OL phosphate (CAS 84522-15-6, C18H16NO6P) is a chemical compound with a molecular weight of 373.30 g/mol. It is primarily recognised for its application as a chromogenic substrate in various biological staining procedures. Its role in visualizing enzymatic activity makes it a valuable reagent in diagnostic and research settings, particularly within cell biology, hematology, and histology.
Chromogenic Substrate in Histochemistry
Naphthol AS-OL phosphate serves as a substrate for phosphatases in histochemical staining. Enzymatic dephosphorylation liberates naphthol, which then couples with a diazonium salt to form an insoluble azo dye at the site of enzyme activity, aiding in tissue analysis.
Diagnostic Staining in Hematology
In hematology, this compound is utilised for the detection of specific enzyme activities within blood cells. This assists in the differential diagnosis and classification of various blood disorders and malignancies.
Research in Cell Biology
Researchers employ Naphthol AS-OL phosphate to study enzyme localization and activity within cells. This helps in understanding cellular processes, signalling pathways, and the physiological or pathological status of cells.
| Molecular weight | 373.30 |
|---|---|
| Empirical formula | C18H16NO6P |
| Assay | ≥30% |
| Storage temperature | 2-8°C |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is Naphthol AS-OL phosphate used for?
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Naphthol AS-OL phosphate is used as a chromogenic substrate for enzyme detection in histochemistry and hematology, particularly for visualizing phosphatase activity in biological samples for research and diagnostic purposes.
What are the CAS number and formula for Naphthol AS-OL phosphate?
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The CAS number is 84522-15-6, and the empirical formula (Hill notation) is C18H16NO6P.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies Naphthol AS-OL phosphate with an assay of ≥30%. We do not represent this product as USP, BP, or EP grade.
How should Naphthol AS-OL phosphate be handled safely?
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Handle Naphthol AS-OL phosphate with appropriate personal protective equipment, including a dust mask type N95 (US), eyeshields, and gloves. Avoid breathing dust and ensure good ventilation. It is classified as a warning substance (GHS07) and may cause skin irritation (H315), eye irritation (H319), and respiratory irritation (H335).
How is Naphthol AS-OL phosphate stored and shipped?
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Naphthol AS-OL phosphate should be stored at 2-8°C. Tech Serve Solutions exports chemicals globally, adhering to all necessary shipping regulations for hazardous materials.
How can I request a sample or quote for Naphthol AS-OL phosphate?
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To request a sample or a quote, please contact our sales team through the website or by phone, providing the product name and CAS number (84522-15-6).
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