3-Indoleglyoxylyl chloride
3-Indoleglyoxylyl chloride (CAS 22980-09-2), with the molecular formula C10H6ClNO2 and a molecular weight of 207.61 g/mol, is a key intermediate in organic synthesis. This compound serves as a versatile building block for the preparation of various complex molecules, including potential pharmaceutical agents. Its applications span the synthesis of inhibitors targeting specific enzymes and the development of novel therapeutic compounds.
- IUPAC
- α-Oxoindole-3-acetyl chloride,2-(3-Indolyl)-2-oxoacetyl chloride,NSC 128332
- Synonyms
- α-Oxoindole-3-acetyl chloride2-(3-Indolyl)-2-oxoacetyl chlorideNSC 128332
Preparation of Dual IGF-1R/SRC Inhibitors
3-Indoleglyoxylyl chloride is utilised as a reactant in the synthesis of compounds designed to inhibit both Insulin-like Growth Factor 1 Receptor (IGF-1R) and Src kinase. This is relevant for research into targeted cancer therapies.
Antileishmanial Agent Synthesis
This chemical serves as a precursor for the preparation of indolylglyoxylamides, a new class of agents being investigated for their potential efficacy against leishmaniasis.
Anticancer Agent Development
It is employed in the synthesis of glyoxyl analogues of indole phytoalexins, which are being explored for their anticancer properties.
Diastereoselective Synthesis of Heptacyclic Cores
3-Indoleglyoxylyl chloride is a reactant in the diastereoselective synthesis of the complex heptacyclic core structure found in dragmacidin E.
HIV-1 Inhibitor Synthesis
The compound is used in the preparation of benzoylmethylpyrrolopyridinylethanedione derivatives, investigated for their potential as HIV-1 inhibitors.
Selective CDK4/Cyclin D1 Inhibitor Research
It serves as a reactant for creating fascaplysin-inspired diindolyl compounds, which are studied for their selective inhibition of CDK4/cyclin D1.
| Molecular weight | 207.61 |
|---|---|
| Empirical formula | C10H6ClNO2 |
| Assay | 98% |
| Storage temperature | 2-8°C |
| Application | • Reactant for preparation of dual IGF-1R/SRC inhibitors1• Reactant for preparation of indolylglyoxylamides as a new class of antileishmanial agents2• Reactant for preparation of glyoxyl analogs of indole phytoalexins as anticancer agents3• Reactant for diastereoselective synthesis of heptacyclic core of dragmacidin E4• Reactant for preparation of benzoylmethylpyrrolopyridinylethanedione as HIV-1 inhibitor5• Reactant for preparation of fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D16 |
| Melting point | 138 °C (dec.)(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |
|---|---|
| Transport (UN / ADR) | UN 1759 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 26-27-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Indoleglyoxylyl chloride used for?
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3-Indoleglyoxylyl chloride is used as a reactant in the preparation of various complex organic molecules, including potential pharmaceutical agents like dual IGF-1R/SRC inhibitors, antileishmanial agents, anticancer agents, HIV-1 inhibitors, and selective CDK4/cyclin D1 inhibitors.
What is the CAS number and molecular formula for 3-Indoleglyoxylyl chloride?
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The CAS number is 22980-09-2 and the molecular formula is C10H6ClNO2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Indoleglyoxylyl chloride with an assay of 98%. We do not represent this product as USP, BP, EP or any other pharmacopoeia grade.
How should 3-Indoleglyoxylyl chloride be handled safely?
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3-Indoleglyoxylyl chloride is a Danger substance (GHS05) and causes severe skin burns and eye damage (H314). Handling requires appropriate personal protective equipment including eyeshields, faceshields, gloves, and suitable respiratory protection (e.g., N100 respirator). Always follow P280, P305 + P351 + P338, and P310 safety precautions.
How is 3-Indoleglyoxylyl chloride packed and shipped?
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3-Indoleglyoxylyl chloride is shipped as UN 1759, Hazard Class 8, Packing Group II. Specific packing and shipping details can be provided upon request, adhering to all relevant international export regulations.
How can I request a sample or quote for 3-Indoleglyoxylyl chloride?
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To request a sample or a quotation for 3-Indoleglyoxylyl chloride, please contact our sales department via the website or by phone, providing your specific requirements.
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