3-Indoleacetonitrile
3-Indoleacetonitrile (CAS 771-51-7, C10H8N2) is a heterocyclic organic compound with a molecular weight of 156.18 g/mol. As a key building block in chemical synthesis, it serves as a crucial reactant for the development of various complex molecules. Its applications span the creation of potential anticancer immunomodulators, histone deacetylase inhibitors, kinase inhibitors, and agrochemicals, demonstrating its versatility in advanced chemical research and development.
- IUPAC
- (3-Indolyl)acetonitrile,3-(Cyanomethyl)indole,IAN,Indolylacetonitrile,NSC 523272
- Synonyms
- (3-Indolyl)acetonitrile3-(Cyanomethyl)indoleIANIndolylacetonitrileNSC 523272
Pharmaceutical Research
3-Indoleacetonitrile is employed in the synthesis of novel therapeutic agents, including potential anticancer immunomodulators, histone deacetylase inhibitors, kinase inhibitors, and Kv7/KCNQ potassium channel activators.
Agrochemical Development
This compound serves as a precursor in the preparation of certain pesticides, contributing to the development of new crop protection solutions.
Metabolic Disease Research
It is utilised in the synthesis of agonists for the Farnesoid X Receptor (FXR), which are being investigated for the treatment of atherosclerosis.
Neuroscience Research
3-Indoleacetonitrile is a reactant in the development of butyrylcholinesterase inhibitors and Kinesin-Specific MKLP-2 Inhibitors, relevant to neurological studies.
| Molecular weight | 156.18 |
|---|---|
| Empirical formula | C10H8N2 |
| Assay | 98% |
| Boiling point | 157-160 °C/0.2 mmHg(lit.) |
| Application | Reactant for preparation of:• Tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators1• Histone deacetylase inhibitors2• Potential kinase inhibitors3• Kv7/KCNQ potassium channel activators4• Kinesin-Specific MKLP-2 Inhibitor5• Pesticides6• Potential PET cancer imaging agents7• Agonists of the Farnesoid X Receptor (FXR) as atherosclerosis treatment8• Butyrylcholinesterase inhibitors9• Necroptosis inhibitors10 |
| Melting point | 33-36 °C(lit.) |
Hazard statements
- H302Harmful if swallowed
- H312Harmful in contact with skin
- H332Harmful if inhaled
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Flash point | 112 °C / 233.6 °F |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xn |
| Risk statements (R) | 20/21/22 |
| Safety statements (S) | 36/37 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Indoleacetonitrile used for?
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3-Indoleacetonitrile is primarily used as a reactant in chemical synthesis for the preparation of compounds with potential applications in pharmaceuticals, agrochemicals, and various research fields.
What are the CAS number and formula for 3-Indoleacetonitrile?
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The CAS number for 3-Indoleacetonitrile is 771-51-7, and its empirical formula is C10H8N2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Indoleacetonitrile with an assay of 98%. We do not represent this product as USP, BP, or EP grade.
What are the safety considerations when handling 3-Indoleacetonitrile?
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3-Indoleacetonitrile is classified as harmful if swallowed, in contact with skin, or if inhaled (H302-H312-H332). Appropriate personal protective equipment, including a dust mask (type N95), eyeshields, and gloves, should be used.
How is 3-Indoleacetonitrile packed and shipped?
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Tech Serve Solutions exports fine chemicals globally. Specific packaging details for 3-Indoleacetonitrile will be confirmed upon order, adhering to international shipping regulations.
How can I request a sample or quote for 3-Indoleacetonitrile?
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To request a sample or a quote for 3-Indoleacetonitrile, please contact our sales team through the dedicated portal on our website.
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