3-Fluorophenylmagnesium bromide solution
3-Fluorophenylmagnesium bromide solution (CAS: 17318-03-5; FC 6H4MgBr) is an organometallic compound supplied by Tech Serve Solutions. This Grignard reagent, with a molecular weight of 199.30, is primarily utilised in chemical synthesis. It is supplied as a 0.5 M solution in Tetrahydrofuran (THF), requiring storage at 2-8°C due to its reactivity. Its properties make it valuable for introducing the 3-fluorophenyl group in various organic transformations.
Organometallic Synthesis
As a Grignard reagent, 3-Fluorophenylmagnesium bromide solution is a versatile nucleophile for carbon-carbon bond formation in organic synthesis. It reacts with electrophiles such as aldehydes, ketones, esters, and epoxides to construct more complex molecular architectures.
Fluorinated Aromatic Compound Synthesis
This reagent serves as a key building block for introducing the 3-fluorophenyl moiety into organic molecules. Fluorinated compounds are of significant interest in pharmaceuticals, agrochemicals, and material science due to their unique electronic and lipophilic properties.
Pharmaceutical Intermediate Preparation
It can be employed in the multi-step synthesis of active pharmaceutical ingredients (APIs) and drug discovery programmes. The incorporation of fluorine can modulate a drug candidate's metabolic stability, binding affinity, and bioavailability.
| Molecular weight | 199.30 |
|---|---|
| Linear formula | FC6H4MgBr |
| Boiling point | 65 °C |
| Density | 0.936 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H314Causes severe skin burns and eye damage
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US) |
|---|---|
| Flash point | -21 °C / -5.8 °F |
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 1 |
| Hazard codes (EU) | F,C |
| Risk statements (R) | 11-14-19-34-37-40 |
| Safety statements (S) | 16-26-36/37/39-45 |
| Supplemental hazards | May form explosive peroxides., Reacts violently with water. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluorophenylmagnesium bromide solution used for?
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3-Fluorophenylmagnesium bromide solution is primarily used in organic synthesis as a Grignard reagent for forming carbon-carbon bonds and introducing the 3-fluorophenyl group into molecules, particularly in the preparation of fluorinated aromatic compounds and pharmaceutical intermediates.
What is the CAS number and chemical formula?
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The CAS number is 17318-03-5 and the linear chemical formula is FC 6H4MgBr.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies this product as a 0.5 M solution in Tetrahydrofuran (THF). TSS does not represent this product as USP, BP, or EP grade; it is intended for research and chemical synthesis purposes.
How should 3-Fluorophenylmagnesium bromide solution be handled and stored safely?
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This compound is a Danger hazard, flammable, causes severe skin burns and eye damage, and may cause respiratory irritation. It may form explosive peroxides and reacts violently with water. Handle under an inert atmosphere in a well-ventilated area, wearing appropriate personal protective equipment including face shields, gloves, and respirators. Store at 2-8°C and away from water and incompatible materials.
Is 3-Fluorophenylmagnesium bromide solution shipped internationally?
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Yes, Tech Serve Solutions is a specialist global supplier and exporter of fine chemicals, including 3-Fluorophenylmagnesium bromide solution, and can facilitate international shipping. Please contact us for specific export details and compliance.
How can I request a quote or sample?
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To request a quote or sample of 3-Fluorophenylmagnesium bromide solution, please visit the Tech Serve Solutions website or contact our sales team directly with your requirements.
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