3-Fluorophenylzinc iodide solution
3-Fluorophenylzinc iodide solution (CAS: 307496-28-2; Formula: FC6H4ZnI; MW: 287.39) is a versatile organozinc reagent supplied by Tech Serve Solutions. This solution, typically at 0.5 M in THF, is highly reactive and finds application in various organic synthesis pathways. It is particularly useful for forming carbon-carbon bonds through cross-coupling reactions, offering a reliable method for introducing the 3-fluorophenyl moiety into complex molecules. Handling requires strict adherence to safety protocols due to its flammability and reactivity.
Cross-Coupling Reactions
This organozinc iodide is an effective nucleophile in various palladium-catalyzed cross-coupling reactions, such as Negishi couplings. It facilitates the formation of new carbon-carbon bonds by reacting with aryl or vinyl halides and triflates.
Organic Synthesis
It serves as a valuable building block in multi-step organic syntheses, enabling the regioselective introduction of the 3-fluorophenyl group into complex organic structures.
Pharmaceutical Intermediate Synthesis
The reagent can be employed in the synthesis of pharmaceutical intermediates where a fluorinated phenyl ring is a required structural element for biological activity.
| Molecular weight | 287.39 |
|---|---|
| Linear formula | FC6H4ZnI |
| Density | 0.995 g/mL at 25 °C |
| Concentration | 0.5 M in THF |
| Storage temperature | 2-8°C |
Hazard statements
- H225Highly flammable liquid and vapour
- H319Causes serious eye irritation
- H335May cause respiratory irritation
- H351Suspected of causing cancer
Precautionary statements
- P210Keep away from heat, sparks and open flames. No smoking
- P261Avoid breathing dust, fume, gas or vapours
- P281Use personal protective equipment as required
- P305IF IN EYES
| Flash point | -17 °C / 1.4 °F |
|---|---|
| Transport (UN / ADR) | UN 2924 8(3) / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | F,Xn |
| Risk statements (R) | 11-14-19-36/37-40 |
| Safety statements (S) | 16-26-36/37 |
| Supplemental hazards | May form explosive peroxides. |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-Fluorophenylzinc iodide solution used for?
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3-Fluorophenylzinc iodide solution (CAS: 307496-28-2) is primarily used in organic synthesis for cross-coupling reactions, such as Negishi couplings, to introduce the 3-fluorophenyl group into organic molecules. It is also valuable in the synthesis of pharmaceutical intermediates.
What are the CAS number and formula for this product?
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The CAS number is 307496-28-2, and the molecular formula is FC6H4ZnI.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-Fluorophenylzinc iodide solution at a concentration of 0.5 M in THF. We do not represent this product as USP, BP, or EP grade; it is suitable for research and general synthesis purposes.
What are the primary safety concerns when handling 3-Fluorophenylzinc iodide solution?
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This solution is highly flammable (flash point -17 °C) and can form explosive peroxides. It is also an irritant to the eyes and respiratory system and is suspected of causing cancer. Strict handling procedures, including working under inert atmosphere and avoiding ignition sources, are mandatory.
How is 3-Fluorophenylzinc iodide solution packed and shipped?
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As per the UN 2924 classification, this product is shipped as a hazardous material, likely under specific conditions to maintain stability and comply with transport regulations for flammable liquids and corrosive solids.
How can I request a sample or quote for 3-Fluorophenylzinc iodide solution?
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To request a sample or a quote, please contact our sales department via the website or by phone, providing the product name and CAS number (307496-28-2).
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