3-(Difluoromethoxy)benzenesulfonyl chloride
3-(Difluoromethoxy)benzenesulfonyl chloride (CAS: 351003-38-8) is a valuable organic building block with the molecular formula F₂CHOC₆H₄SO₂Cl and a molecular weight of 242.63 g/mol. This fluorinated compound, featuring a difluoromethoxy group and a sulfonyl chloride moiety, is primarily utilised in chemical synthesis. It serves as a key intermediate for introducing the difluoromethoxyaryl sulfonyl group into various molecular structures, particularly in the development of novel pharmaceutical agents and agrochemicals.
Pharmaceutical Intermediate
This compound is employed as a building block in the synthesis of active pharmaceutical ingredients (APIs). The incorporation of the difluoromethoxy group can modulate pharmacokinetic properties such as lipophilicity and metabolic stability.
Agrochemical Synthesis
It serves as a key intermediate in the development of new pesticides and herbicides. The unique electronic properties conferred by the difluoromethoxy group can enhance the efficacy and selectivity of agrochemical products.
Organic Synthesis Reagent
As a sulfonyl chloride derivative, it can participate in various coupling and derivatisation reactions. It is useful for introducing the 3-(difluoromethoxy)benzenesulfonyl group into organic molecules for research and development purposes.
| Molecular weight | 242.63 |
|---|---|
| Linear formula | F2CHOC6H4SO2Cl |
| Assay | 97% |
| Boiling point | 233-234 °C(lit.) |
| Density | 1.509 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5100(lit.) |
Hazard statements
- H314Causes severe skin burns and eye damage
Precautionary statements
- P280Wear protective gloves, clothing and eye/face protection
- P305IF IN EYES
- P310Immediately call a POISON CENTER or doctor
| Protective equipment | Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
|---|---|
| Flash point | 97 °C / 206.6 °F |
| Transport (UN / ADR) | UN 3265 8 / PGII |
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | C |
| Risk statements (R) | 34 |
| Safety statements (S) | 22-26-36/37/39-45 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Difluoromethoxy)benzenesulfonyl chloride used for?
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3-(Difluoromethoxy)benzenesulfonyl chloride is used as a building block and intermediate in organic synthesis, particularly for pharmaceuticals and agrochemicals, enabling the introduction of the 3-(difluoromethoxy)benzenesulfonyl moiety.
What is the CAS number and molecular formula?
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The CAS number is 351003-38-8, and the linear molecular formula is F₂CHOC₆H₄SO₂Cl.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-(Difluoromethoxy)benzenesulfonyl chloride with an assay of 97%. This is a technical/research grade material, and TSS does not represent it as USP, EP, or BP grade.
How should 3-(Difluoromethoxy)benzenesulfonyl chloride be handled?
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This compound is corrosive and causes severe skin burns and eye damage (H314). Handle with appropriate personal protective equipment, including gloves, goggles, and a facesheild or full-face respirator. Ensure adequate ventilation. Refer to the Safety Data Sheet for detailed handling procedures.
Is this chemical controlled or scheduled?
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Based on the provided data, 3-(Difluoromethoxy)benzenesulfonyl chloride is not indicated as a controlled or scheduled substance.
How is this chemical packed, shipped, and exported?
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This product is shipped as UN 3265, Class 8, Packing Group II, indicating it is a corrosive liquid, acidic, organic, n.o.s. Tech Serve Solutions complies with all relevant international shipping and export regulations.
How can I request a quote or sample?
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Please contact the Tech Serve Solutions sales team via our website or direct contact details to request a quote or sample for 3-(Difluoromethoxy)benzenesulfonyl chloride.
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