3-(Difluoromethoxy)aniline
3-(Difluoromethoxy)aniline (CAS: 22236-08-4), with the molecular formula CHF2OC6H4NH2 and a molar mass of 159.13 g/mol, is a fluorinated organic compound. It serves as a valuable building block in chemical synthesis, particularly for introducing the difluoromethoxy moiety into larger molecules. This compound is primarily utilised in research and development settings for the creation of novel chemical entities, including pharmaceuticals and agrochemicals.
Pharmaceutical Intermediate
3-(Difluoromethoxy)aniline is employed as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its difluoromethoxy group can impart desirable pharmacokinetic properties to drug candidates.
Agrochemical Synthesis
This compound is utilised in the development of new pesticides and herbicides. The introduction of fluorine atoms can enhance the efficacy and metabolic stability of agrochemical products.
Material Science
As a building block, it can be incorporated into polymers or other advanced materials where the difluoromethoxy functionality may confer unique physical or chemical properties.
Research and Development
It serves as a versatile reagent in organic synthesis laboratories for exploratory research, enabling the creation of diverse fluorinated organic molecules.
| Molecular weight | 159.13 |
|---|---|
| Linear formula | CHF2OC6H4NH2 |
| Assay | 97% |
| Boiling point | 201-202 °C(lit.) |
| Density | 1.276 g/mL at 25 °C(lit.) |
| Refractive index | n20/D 1.5100(lit.) |
Hazard statements
- H315Causes skin irritation
- H319Causes serious eye irritation
- H335May cause respiratory irritation
Precautionary statements
- P261Avoid breathing dust, fume, gas or vapours
- P305IF IN EYES
| Protective equipment | dust mask type N95 (US), Eyeshields, Gloves |
|---|---|
| Water hazard class (WGK, DE) | 3 |
| Hazard codes (EU) | Xi |
| Risk statements (R) | 36/37/38 |
| Safety statements (S) | 26-36 |
Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.
Documentation
Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.
Supply & logistics
Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.
What is 3-(Difluoromethoxy)aniline used for?
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3-(Difluoromethoxy)aniline is primarily used as a building block in chemical synthesis for the development of pharmaceuticals, agrochemicals, and novel materials. It is valuable for introducing the difluoromethoxy group into organic molecules.
What is the CAS number and formula for 3-(Difluoromethoxy)aniline?
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The CAS number for 3-(Difluoromethoxy)aniline is 22236-08-4, and its molecular formula is CHF2OC6H4NH2.
What grade and purity does Tech Serve Solutions supply?
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Tech Serve Solutions supplies 3-(Difluoromethoxy)aniline with a minimum assay of 97%. We do not represent this product as USP, BP, EP or other pharmacopoeia grades.
How should 3-(Difluoromethoxy)aniline be handled safely?
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3-(Difluoromethoxy)aniline is classified as a warning substance, causing skin irritation (H315), eye irritation (H319), and respiratory irritation (H335). Use in a well-ventilated area with appropriate personal protective equipment including a dust mask (N95), eyeshields, and gloves. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid contact with skin and eyes. P261, P305 + P351 + P338.
Is 3-(Difluoromethoxy)aniline a controlled substance?
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Based on the provided data, there is no indication that 3-(Difluoromethoxy)aniline is a controlled substance.
How is 3-(Difluoromethoxy)aniline packed, shipped, and exported?
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Tech Serve Solutions, as a specialist global supplier and exporter, packs and ships fine chemicals like 3-(Difluoromethoxy)aniline in compliance with international regulations for hazardous materials, ensuring safe and secure transport worldwide.
How can I request a sample or quote for 3-(Difluoromethoxy)aniline?
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To request a sample or a quote for 3-(Difluoromethoxy)aniline, please contact our sales team through the website or by phone, providing your specific requirements.
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