3-Chlorophenylhydrazine hydrochloride

CAS 2312-23-4ClC6H4NHNH2 · HClChemical Synthesis

3-Chlorophenylhydrazine hydrochloride (CAS 2312-23-4) is an organic compound with the linear formula ClC₆H₄NHNH₂ · HCl and a molecular weight of 179.05 g/mol. This chemical acts as a valuable building block in organic synthesis. Its primary applications lie in the preparation of complex heterocyclic compounds, particularly those with fused ring systems, serving as a key intermediate in the development of novel chemical entities.

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3-Chlorophenylhydrazine hydrochloride (ClC6H4NHNH2 · HCl) — chemical structure, CAS 2312-23-4; Chemistry, fine chemical supplied by Tech Serve Solutions

Building BlocksChemical SynthesisHydrazinesNitrogen CompoundsOrganic Building Blocks

01 /Applications

Synthesis of Pyrazolo[4,3-c]quinolin-4(5H)-one Derivatives

3-Chlorophenylhydrazine hydrochloride is utilised in the preparation of 1-(3-chlorophenyl)-3,5-diphenyl-1H-pyrazolo[4,3-c]quinolin-4(5H)-one. This reaction highlights its utility in constructing polycyclic heterocyclic frameworks.

Preparation of Benzo[i,j]pyrazolo[3,4-b]quinolizin-8-one Structures

This compound serves as a precursor for the synthesis of 11-(3-chlorophenyl)-9-phenyl-5,6-dihydro-4H,11H-benzo[i,j]-pyrazolo[3,4-b]quinolizin-8-one. Such syntheses are important for generating complex fused ring systems.

Intermediate for Substituted Pyrazole Synthesis

3-Chlorophenylhydrazine hydrochloride is employed in the creation of pyrazole derivatives, such as 1-(3-chlorophenyl)-3-(cyclohexyl)-5-(4-phenoxyphenyl)pyrazole. This demonstrates its role in accessing diverse substituted heterocycles.

02 /Properties

Molecular weight	179.05
Linear formula	ClC6H4NHNH2 · HCl
Assay	≥97.0% (AT)
Application	3-Chlorophenylhydrazine hydrochloride has been used in the preparation of:• 1-(3-chlorophenyl)-3,5-diphenyl-1H-pyrazolo[4,3-c]quinolin-4(5H)-one1• 11-(3-chlorophenyl)-9-phenyl-5,6-dihydro-4H,11H-benzo[i,j]- pyrazolo[3,4-b]quinolizin-8-one1• 1-(3-chlorophenyl)-3-(cyclohexyl)-5-(4-phenoxy phenyl)pyrazole2
Melting point	240-245 °C (dec.)(lit.)

03 /Safety & handling

GHS hazard pictogram: Harmful / irritant (GHS07) — Harmful / irritant

GHS hazard pictogram: Health hazard (GHS08) — Health hazard

Danger

Hazard statements

H302Harmful if swallowed
H334May cause allergy or asthma symptoms if inhaled

Precautionary statements

P261Avoid breathing dust, fume, gas or vapours
P342

Protective equipment	dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Water hazard class (WGK, DE)	3
Hazard codes (EU)	Xn
Risk statements (R)	22-43
Safety statements (S)	36/37

Hazard information is provided for guidance. Always consult the product Safety Data Sheet (SDS), available on request, before handling.

04 /Identifiers & registry

CAS number

2312-23-4

MDL number

MFCD00012935

Beilstein registry

3565828

05 /Quality & supply

Documentation

Every batch ships with a Certificate of Analysis covering assay, identity and purity; the grade is confirmed against your enquiry. Safety Data Sheets and technical data sheets are available on request.

Supply & logistics

Samples for technical evaluation; bulk MOQ by grade and packaging. In-stock material ships in 7–10 working days, worldwide, with full export documentation.

06 /Frequently asked questions

What is 3-Chlorophenylhydrazine hydrochloride used for?

3-Chlorophenylhydrazine hydrochloride is primarily used as a building block in organic synthesis for the preparation of complex heterocyclic compounds, including pyrazoloquinolinones and substituted pyrazoles.

What are the CAS number and formula for 3-Chlorophenylhydrazine hydrochloride?

The CAS number is 2312-23-4 and the linear formula is ClC₆H₄NHNH₂ · HCl.

What grade and purity does Tech Serve Solutions supply?

Tech Serve Solutions supplies 3-Chlorophenylhydrazine hydrochloride with an assay of ≥97.0% (AT). This is a technical/research grade material, and TSS does not represent it as USP, BP, EP, or any other pharmacopoeia grade.

What are the main safety concerns when handling 3-Chlorophenylhydrazine hydrochloride?

3-Chlorophenylhydrazine hydrochloride is classified as dangerous. It is harmful if swallowed (H302) and can also be harmful if inhaled (H334). Appropriate personal protective equipment, including a dust mask type N95, eyeshields, faceshields, and gloves, should be used. Handle with care in a well-ventilated area and avoid breathing dust.